2',3'-Dideoxyadenosine 5'-triphosphate

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产品名称：2',3'-Dideoxyadenosine 5'-triphosphate

产品别名：ddATP;

CAS号：24027-80-3

英文别名：[[(2S,5R)-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

分子量：475.2

分子式：C₁₀H₁₆N₅O₁₁P₃

纯度：≥99%

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保存方法：Store at -20℃

描述：2',3'-Dideoxyadenosine 5'-triphosphate (ddATP) is an in vitro inhibitor of reverse transcriptases from retroviruses, including HIV-1 and visna (K_is = 20 and 37 nM, respectively).^1,2,3 It also blocks, in vitro, mammalian and bacterial DNA polymerases.^4,5 ddATP, produced intracellularly by the phosphorylation of exogenously supplied 2’,3’-dideoxyadenosine, competes with dATP, resulting in chain termination.^4,5 Because of this activity, dideoxynucleoside 5’-triphosphates, including ddATP, are used to terminate chain extension produced by the Taq polymerase used in polymerase chain reactions.⁶ It is also an antagonist of the purinergic receptor P2X_2/3 (pIC₅₀ = 6.5).⁷

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