Thrombin Activation peptide fragment 1

【Molecular Wt.】17/64 KDa

【Description】Thrombin is an active enzyme in the earliest steps of the blood clot formation, generated from its circulating inactive precursor prothrombin. Thrombin is a glycoprotein formed by two peptides chains of 36 and 259 amino acids linked by disulfure bonds. Three important sites have been identified on the surface of the enzyme: The catalytic site that confers to the molecule its serine protease activity, the exosite one responsible for the binding of the substrate (fibrinogen or thrombin receptor) and the exosite two responsible for the binding of antithrombin III and inactivation of thrombin. Gamma Thrombin is a proteolyzed form of Alpha Thrombin. Gamma Thrombin consists of four chains (A, B1, B5, B4) with a disulfide link between the A peptide and the B5 peptide.

【Species Reactivity】Human;Mouse;Rat;Guinea Pig

【Tested applications】WB

【Antibody type】Rabbit polyclonal Antibody

【Immunogen】KLH conjugated synthetic peptide derived from human Thrombin Activation peptide fragment 1 51-150/622

【Positive control】Expressed by the liver and secreted in plasma.

【Conjugate】Non-conjugated

【Alternative names】Activation peptide fragment 1
coagulation factor II
prothrombin
F2
Cf-2
Cf2
FII
F 2
coagulation factor II (thrombin)
Coagulation factor II
Coagulation factor II precursor
F2
Factor II
Factor-II
Prothrombin
prothrombin B-chain
PT
serine protease
THRB
THRB_HUMAN
Thrombin.

【Form】Liquid

【Stroage】Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.

【Stroage Buffer】0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

【Isotype】IgG

【Purity】affinity purified by Protein A

【Subcellular location】Secreted, extracellular space.

【Background References】

【DatasheetURL】https://www.huabio.com/upload/ER1917-70.pdf

【Uniprot ID】SwissProt: P00734 Human

【Raised in】Rabbit

【Clone No.】