现货，Hesperadin，selleck，美国进口，Aurora Kinase YZ剂，CAS号: 422513-13-1，目录号S1529

Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate. Growth of cultured bloodstream forms (BF) was also sensitive to Hesperadin with an IC50 of 50 nM. It blocked nuclear division and cytokinesis, but not other aspects of the cell cycle. Mammalian cells treated with Hesperadin enter anaphase in the presence of numerous monooriented chromosomes, many of which may have both sister kinetochores attached to one spindle pole (syntelic attachment). Hesperadin also causes cells arrested by taxol or monastrol to enter anaphase within <1 h, whereas cells in nocodazole stay arrested for 3-5 h. ^[1][2][3]

• The cell cycle as a therapeutic target against Trypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms Neal Jetton, Karen G. Rothberg,et al. Mol Microbiol 2009 April;72(2): 442–458
• The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint Silke Hauf,Richard W. Cole,et al. The Journal of Cell Biology 2003;161：281–294
• Mechanism of Aurora B Activation by INCENP and Inhibition by Hesperadin Fabio Sessa,Marina Mapelli,et al. Molecular Cell April 29, 2005;18：379–391

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