现货，SB 202190，selleck，美国进口，p38 MAPK YZ剂，CAS号: 152121-30-7，目录号 S1077_详细资料

产品信息

保质期：两年保存条件：零下20摄氏度低温保存数量：大量英文名： SB 202190 CAS号： 152121-30-7 供应商： selleck中国广州办事处规格： 250 U/25mg

规格： 250 U 产品价格：￥945

规格： 25mg 产品价格：￥945

S1077 SB 202190
信号转导通路: MAPK >> p38 MAPK >> p38 MAPK YZ剂 >> SB 202190
技术数据:

分子量(MW): 331.34

化学式:
C₂₀H₁₄N₃OF

溶解度: DMSO ≥66mg/mL Water <1mg/mL Ethanol ≥32mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 152121-30-7

生物活性

SB202190 enhanced the growth of THP-1 and MV4-11 cells. In the presence of SB202190, the values for the farnesyltransferase inhibitor FPT inhibitor II and MEK inhibitor U0126 were significantly decreased.SB202190 increased the phosphorylation of C-Raf and extracellular regulated kinase (ERK). ^[1]
SB202190 suppressed the kinase activity of p38, leading to inhibition of activation of MAPKAPK2 and then the subsequent phosphorylation of hsp27 in LPS-treated macrophages both in vitro and in vivo. ^[2]
SB202190 blocked p38 half maximally at 30 nM. Concentrations as high as 30,000 nM did not inhibit ERK and JNK activity. ^[3]

参考文献

Activation of the ras genes in malignant and premalignant colorectal tumors. Glarakis IS, et al. Oncol Rep. 1998 Nov-Dec;5(6):1451-4.

Transformation of mammalian cells by constitutively active MAP kinase kinase Mansour SJ,et al. Science 1994;265(5174):966-970

p38 MAP kinase inhibition promotes primary tumour growth via VEGF independent mechanism. O'Sullivan AW,et al. World J Surg Oncol. 2009 Nov 15;7:89.

客户反馈数据

C, Jurkat cells with SB202190 at 1, 5, and 10M were tested, and a decreased SRP72 expression was found when using at 10M (lanes 8 and 9). D, results were analyzed and RUA illustrated, finding significant results at 10M at 240 versus 0 and 120 versus 0 min (p0.05).

C, effect of SB202190 (1, 5, and 10M) on SRP72 phosphorylation was tested. A decreased intensity of SRP72 expression when used at 1M (240 min) and 5 and 10M (120 and 240 min) was found. D, RUA illustrated obtaining significant results at concentration 5 and 10M at 120 versus 0 and 240 versus 0 min. * indicates p0.05.

We used real time RT-PCR to investigate the effects of SB202190 on SRP72 mRNA expression. All the samples were treated under the same experimental conditions used in protein tests done by WB, and phosphorylation was measured indirectly by IP-WB. The results did not show significant changes on the mRNA expression of SRP72 after the treatment with these inhibitors.

如果需要长期保存，请于零下二十度低温保存。

禁止用于人体及ZL！

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20 ° C ，抗体及蛋白等产品建议-60℃。YZ剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

温馨提示：不可用于临床ZL。

规格：	250 U	产品价格：	￥945
规格：	25mg	产品价格：	￥945

分子量(MW):	331.34
化学式:	C₂₀H₁₄N₃OF
溶解度:	DMSO ≥66mg/mL Water <1mg/mL Ethanol ≥32mg/mL
纯度:	>99%
稳定性:	at -20℃ 2 years
CAS号:	152121-30-7

	C, Jurkat cells with SB202190 at 1, 5, and 10M were tested, and a decreased SRP72 expression was found when using at 10M (lanes 8 and 9). D, results were analyzed and RUA illustrated, finding significant results at 10M at 240 versus 0 and 120 versus 0 min (p0.05).
	C, effect of SB202190 (1, 5, and 10M) on SRP72 phosphorylation was tested. A decreased intensity of SRP72 expression when used at 1M (240 min) and 5 and 10M (120 and 240 min) was found. D, RUA illustrated obtaining significant results at concentration 5 and 10M at 120 versus 0 and 240 versus 0 min. * indicates p0.05.
	We used real time RT-PCR to investigate the effects of SB202190 on SRP72 mRNA expression. All the samples were treated under the same experimental conditions used in protein tests done by WB, and phosphorylation was measured indirectly by IP-WB. The results did not show significant changes on the mRNA expression of SRP72 after the treatment with these inhibitors.

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现货，SB 202190，selleck，美国进口，p38 MAPK YZ剂，CAS号: 152121-30-7，目录号 S1077

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