现货，ZM-447439，selleck，美国进口，Aurora Kinase YZ剂，CAS号: 331771-20-1，目录号 S1103

ZM-447439 is a potent and selective Aurora B kinase inhibitor with an IC50 of 50 nM, 1 μM and 250 nM for Aurora B, A and C, respectively. Other kinases such as Cdk1 and PLK1 are not inhibited (up to 10 mM). Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. Mitotic Aurora kinases are essential for accurate chromosome segregation during cell division. Forced overexpression of Aurora kinase results in centrosome amplification and multipolar spindles, causing aneuploidy, a hallmark of cancer. ZM447439 does not interfere with other kinases when used up to 5 µM. ZM447439 dose-dependently inhibited proliferation of all three cell lines (BON, QGP-1 and MIP-101) with IC50 values in the nanomolar to low micromolar range. Moreover, aurora kinase inhibition by ZM447439 potently induced apoptosis, which was accompanied by DNA fragmentation and caspase 3 and 7 activation. ^[1][2][3]

• ZM 447439 inhibition of aurora kinase induces Hep2 cancer cell apoptosis in three-dimensional culture Zi-Jie Long,Jie Xu,et al. Cell Cycle 15 May 2008;7:10, 1473-1479
• Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2,and Cenp-E to kinetochores Claire Ditchfield,Victoria L. Johnson,et al. The Journal of Cell Biology 2003;161:267–280
• Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors Georges Pasquet,Christine Lambert-van der Brempt,et al. J. Med. Chem 2006;49:955-970

特定的存储和包装每个产品的信息在产品说明书上都有注明 。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20 ° C ，抗体及蛋白等产品建议-60℃。YZ剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。