现货，LY2228820，selleck，美国进口，p38 MAPK YZ剂，CAS号: 862507-23-1，目录号 S1494

LY2228820 is a novel and potent p38MAPK inhibitor: in vitro kinase enzyme activity showed that the IC50 for p38αMAPK and p38βMAPK were 7 nM and 3 nM, respectively, while that for p38δMAPK, p38γMAPK and a panel of 172 additional kinases was more than 20 µM. Phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, was significantly inhibited by LY in both MM cell lines and LT-BMSCs. ^[1]

• p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications Kenji Ishitsuka,Teru Hideshima,et al. British Journal of Haematology 2008;141:598–606

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