Anti-phospho-IKKi/IKKe(Thr501)磷酸化核因子NFκBYZ蛋白激酶i抗体

本公司经销phospho-IKKi/IKKe（Thr501），磷酸化核因子NFκBYZ蛋白激酶i抗体，克隆类型为polyclonal，宿主来源是Rabbit，phospho-IKKi/IKKe（Thr501）磷酸化核因子NFκBYZ蛋白激酶i抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-7601R
英文名称：Anti-phospho-IKKi/IKKe（Thr501）
中文名称：磷酸化核因子NFκBYZ蛋白激酶i抗体
其他名称：名IKKi/IKKe （phospho T501）;I kappa B kinase epsilon;I-kappa-B kinase epsilon;IkBKE;IKK related kinase epsilon;IKK-E;IKK-epsilon;IKK-i;IKKE;IKKE_HUMAN;IKKepsilon;IKKI;Inducible I kappa B kinase;Inducible I kappa-B kinase;Inducible IkappaB kinase;Inhibitor of kappa light polypeptide gene enhancer in B cells kinase epsilon;Inhibitor of nuclear factor kappa-B kinase subunit epsilon.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 80kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, Rb, cow
产品介绍：Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex ａnd ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.Tissue specificity: Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary ａnd colon.Function : Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex ａnd ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.Subunit : May interact with MAVS/IPS1. Interacts with AZI2. Interacts with SIKE1. Interacts with TICAM1/TRIF, IRF3 ａnd DDX58/RIG-I, interactions are disrupted by the interaction between IKBKE ａnd SIKE1. Interacts with TOPORS; induced by DNA damage. Interacts with CYLD.Subcellular Location : Cytoplasm. Nucleus. Nucleus, PML body. Note=Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent.Tissue Specificity : Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary ａnd colon.Post-translational modifications : Autophosphorylated ａnd phosphorylated by IKBKB/IKKB.Sumoylation by TOPORS upon DNA damage is required for protection of cells against DNA damage-induced cell death. Desumoylated by SENP1.Similarity : Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.Contains 1 protein kinase domain.