Anti-phospho-LLGL1 + LLGL2(Ser650+Ser654)磷酸化相似肿瘤YZ基因HUGL抗体

本公司经销phospho-LLGL1 + LLGL2（Ser650+Ser654），磷酸化相似肿瘤YZ基因HUGL抗体，克隆类型为polyclonal，宿主来源是Rabbit，phospho-LLGL1 + LLGL2（Ser650+Ser654）磷酸化相似肿瘤YZ基因HUGL抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6070R
英文名称：Anti-phospho-LLGL1 + LLGL2（Ser650+Ser654）
中文名称：磷酸化相似肿瘤YZ基因HUGL抗体
其他名称：名LLGL1 + LLGL2（phospho S650 + S654）; DLG4; HGL; HUGL; HUGL1; lethal giant larvae homolog 1; lethal giant larvae homolog 2; Lethal（2） giant larvae protein homolog 1; Lethal（2） giant larvae protein homolog 2; LGL2; LLGL.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 117kDa
纯化方法：affinity purified by Protein A
交叉反应：mo, hu, rat, cow, chik, Gpig, hrs, dog
产品介绍：LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network ａnd is associated with nonmuscle myosin II heavy chain ａnd a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal giant larvae of Drosophila. In fly, the protein＇s ability to localize cell fate determinants is regulated by the atypical protein kinase C （aPKC）. In human, this protein interacts with aPKC-containing complexes ａnd is cortically localized in mitotic cells.Function : Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity ａnd epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation ａnd tissue organization of neuroepithelial cells.Subunit : Associated with nonmuscle myosin II heavy chain. Interacts with PRKCI/aPKC, PARD6B/Par-6 ａnd PARD6A. Interacts with STX4A.Subcellular Location : Cytoplasm, cytoskeleton. Note=Localized to the lateral membrane during the polarization ａnd formation cell-cell contacts.Tissue Specificity : Expressed in brain, kidney, ａnd muscle but is barely seen in heart ａnd placenta. Down-regulated or lost in all cell lines ａnd in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease.Post-translational modifications : Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated at least at Ser-663 by PRKCI.Similarity : Belongs to the WD repeat L（2）GL family.Contains 14 WD repeats.