SLC8钠碘转运体蛋白8抗体

本公司经销SLC8，钠碘转运体蛋白8抗体，克隆类型为polyclonal，宿主来源是Rabbit，SLC8钠碘转运体蛋白8抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6106R
英文名称：Anti-SLC8
中文名称：钠碘转运体蛋白8抗体
其他名称：名AIT; Apical iodide transporter; Electrogenic sodium monocarboxylate cotransporter; SC8_HUMAN; SLC8; SMCT; SMCT1; sodium coupled monocarboxylate transporter 1; Sodium iodide related cotransporter; Sodium iodide-related cotransporter; Sodium-coupled monocarboxylate transporter 1; solute carrier family 5 iodide transporter member 8; Solute carrier family 5 member 8.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 67kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow, chk
产品介绍：Acts as an electrogenic sodium （Na（+）） ａnd chloride （Cl-）-dependent sodium-coupled solute transporter, including transport of monocarboxylates （short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate ａnd butyrate）, lactate, mocarboxylate drugs （nicotinate, benzoate, salicylate ａnd 5-aminosalicylate） ａnd ketone bodies （beta-D-hydroxybutyrate, acetoacetate ａnd alpha-ketoisocaproate）, with a Na（+）:substrate stoichiometry of between 4:1 ａnd 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate ａnd monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer ａnd glioma cell lines. May play a critical role in the entry of L-lactate ａnd ketone bodies into neurons by a process driven by an electrochemical Na（+） gradient ａnd hence contribute to the maintenance of the energy status ａnd function of neurons.Subcellular Location : Apical cell membrane; Multi-pass membrane protein. Tissue Specificity : Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloid lumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colon aberrant crypt foci ａnd colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa ａnd breast tissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors ａnd breast tumors.Similarity : Belongs to the sodium:solute symporter （SSF） （TC 2.A.21） family.