P53 protein(wt-p53)肿瘤YZ基因P53蛋白抗体（野生型P53）

本公司经销P53 protein（wt-p53），肿瘤YZ基因P53蛋白抗体（野生型P53），克隆类型为polyclonal，宿主来源是Rabbit，P53 protein（wt-p53）肿瘤YZ基因P53蛋白抗体（野生型P53）可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0033R
英文名称：Anti-P53 protein（wt-p53）
中文名称：肿瘤YZ基因P53蛋白抗体（野生型P53）
其他名称：名Widespread p53; Wtp53; Antigen NY-CO-13; Cellular tumor antigen p53; Cys 51 Stop; HGNC11998; LFS1; p53; p53 Cellular Tumor Antigen; p53 Tumor Suppressor; Phosphoprotein p53; TP53; Transformation related protein 53; TRP53; Tumor protein p53; Tumour Protein p53.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 53kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, Rb, pig, shp, hrs
产品介绍：The widely studied P53 tumor suppressor gene has been found to contain mutations in over 50% of human cancers. The level of P53 protein is low in normal cells, but is increased in response to DNA damage or various other cellular distress signals. Overexpression of the P53 transcription factor can induce ether cell cycle arrest or apoptosis through transcriptional regulation of several genes including the cell cycle ingibitor P21, DNA repair gene GADD45, ａnd the apoptotic inducer Bax. P53 has also been shown to induce apoptosis by meas of s direct signaling pathway. P53 directly binds to ａnd acts on several cellular protein involved in various pathway, including c-Abl, basal transcription factor TFIIH ａnd WT1. P53 can be functionally inactivated by mutation, binding to DNA tumor virus encoded proteins, such as SV40 large T antigen, Adenovirus E1B ａnd papilloma virus E6 proteins or as a consequence of its interaction with the oncogene-encoded protein MDM2.Function : Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances ａnd cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX ａnd FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity ａnd impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.Subunit : Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 ａnd AXIN1 （By similarity）. Binds DNA as a homotetramer. Interacts with histone acetyltransferases EP300 ａnd methyltransferases HRMT1L2 ａnd CARM1, ａnd recruits them to promoters. Subcellular Location : Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2.Tissue Specificity : Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord ａnd fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord ａnd fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle ａnd breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain ａnd intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.DISEASE : Note=TP53 is found in increased amounts in a wide variety of transformed cells. TP53 is frequently mutated or inactivated in about 60% of cancers. TP53 defects are found in Barrett metaplasia a condition in which the normally stratified squamous epithelium of the lower esophagus is replaced by a metaplastic columnar epithelium. The condition develops as a complication in approximately 10% of patients with chronic gastroesophageal reflux disease ａnd predisposes to the development of esophageal adenocarcinoma.Similarity : Belongs to the p53 family.wtp53广泛的研究发现P53肿瘤YZ基因对50%以上的人类癌症具有YZ突变的功能。P53蛋白水平在正常细胞中表达低，在DNA突变时或各种各样细胞遇难信号时反应增加。该基因突变或缺失是导致许多肿瘤发生的原因。 野生型P53（wt-p53）可诱导细胞凋亡，并通过细胞凋亡YZ肿瘤生长，而P53的突变或缺失则可YZ野生型P53的功能，使得缺陷细胞得以存活下来，从而导致肿瘤发生。P53同时也是细胞凋亡的调控因子。此抗体可用于P53肿瘤YZ基因功能的研究。产品图片Protein: line1, rat brain lysates, 30ug; line2, human colon carcinoma lysates, 30ug; Primary: Anti-wt-p53 （bs-0033R） at 1:200; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bse-0295G） at 1: 3000; ECL excitated the fluorescence; Predicted band size : 53kDObserved band size : 53kDAntigen: bs-0033P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.