重组人内皮素1/EDN1 Human 重组人内皮素1_详细资料

产品信息 重组人内皮素1/EDN1 Human 重组人内皮素1 重组人内皮素1/EDN1 Human 产品编号：HOR-307 产品规格：1mg/5mg/25mg Catalogue Number HOR-307 Synonyms EDN1, EDN-1, ET-1, Endothelin-1, Preproendothelin-1, PPET1, ET1, HDLCQ7. Introduction EDN1 is a powerful mitogen mediator of smooth muscle tone, ａnd inflammatory regulator that is involved in diseases of the airways, pulmonary circulation, ａnd inflammatory lung diseases, both acute ａnd chronic. Endothelin-2 ａnd Endothelin-3 vary from Endothelin-1 by two ａnd six amino acids, respectively, ａnd share homology, particularly at the carboxy terminus with sarafotoxins a-e. The lung has the largest levels of EDN1 secreted by endothelium, smooth muscle, airway epithelium, ａnd a diversity of other cells. ET-1 also circulates in the plasma. Endothelin-1 along with endothelin-2, & endothelin-3 （ET-3） consist of the endothelin family of 21 amino acid peptides manufactured in a variety of cells ａnd tissues, particularly endothelial ａnd epithelial lineages. These endothelins are derivatives from three genes. The endothelins are normally connected with hypertension, though they regulate a diversity of other effects through two G-protein coupled receptors, ET-A ａnd ET-B. The endothelins are derivatives from a precursor peptides using cleavage by metalloproteases for instance endothelin-converting enzymes. Description EDN1 contains 21 amino acids having a molecular mass of 2491.95 Dalton. The EDN1 contains a 2 pair Disulfide bond: Cys1-Cys15 ａnd Cys3-Cys11. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein （1mg/ml） was lyophilized with no additives. Solubility It is recommended to reconstitute the lyophilized EDN1 in sterile 18MΩ-cm H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized EDN1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution EDN1 should be stored at 4°C between 2-7 days ａnd for future use below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles. Purity Greater than 95.0% as determined by RP-HPLC. Amino acid sequence Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

您可能感兴趣的产品

Catalogue Number	HOR-307
Synonyms	EDN1, EDN-1, ET-1, Endothelin-1, Preproendothelin-1, PPET1, ET1, HDLCQ7.
Introduction	EDN1 is a powerful mitogen mediator of smooth muscle tone, ａnd inflammatory regulator that is involved in diseases of the airways, pulmonary circulation, ａnd inflammatory lung diseases, both acute ａnd chronic. Endothelin-2 ａnd Endothelin-3 vary from Endothelin-1 by two ａnd six amino acids, respectively, ａnd share homology, particularly at the carboxy terminus with sarafotoxins a-e. The lung has the largest levels of EDN1 secreted by endothelium, smooth muscle, airway epithelium, ａnd a diversity of other cells. ET-1 also circulates in the plasma. Endothelin-1 along with endothelin-2, & endothelin-3 （ET-3） consist of the endothelin family of 21 amino acid peptides manufactured in a variety of cells ａnd tissues, particularly endothelial ａnd epithelial lineages. These endothelins are derivatives from three genes. The endothelins are normally connected with hypertension, though they regulate a diversity of other effects through two G-protein coupled receptors, ET-A ａnd ET-B. The endothelins are derivatives from a precursor peptides using cleavage by metalloproteases for instance endothelin-converting enzymes.
Description	EDN1 contains 21 amino acids having a molecular mass of 2491.95 Dalton. The EDN1 contains a 2 pair Disulfide bond: Cys1-Cys15 ａnd Cys3-Cys11.
Physical Appearance	Sterile Filtered White lyophilized （freeze-dried） powder.
Formulation	The protein （1mg/ml） was lyophilized with no additives.
Solubility	It is recommended to reconstitute the lyophilized EDN1 in sterile 18MΩ-cm H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.
Stability	Lyophilized EDN1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution EDN1 should be stored at 4°C between 2-7 days ａnd for future use below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
Purity	Greater than 95.0% as determined by RP-HPLC.
Amino acid sequence	Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp.
Usage	Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.