Prospec PRO-318 Factor-VIII Human Recombinant/重组人因子VIII_详细资料

产品信息

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Factor-VIII Human Recombinant/重组人因子VIII
产品编号：PRO-318
产品规格：250IU/500IU/1000IU

Synonyms Coagulation factor VIII, Procoagulant component, Antihemophilic factor, AHF, F8, F8C, F8B, HEMA, FVIII, DXS1253E, F8 protein.

Introduction Coagulation factor VIII participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 ａnd phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma ａnd associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Description Antihemophilic Facor Human Recombinant produced in CHO is a glycosylated polypeptide chain having a total amino acids of 1438 （170kd）ａnd consisting of two dimer chains 80 kD ａnd 90 kD.
The Factor-VIII is purified by proprietary chromatographic techniques.

Source CHO cells （Chinese Hamster Ovarian Cells）.

Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder.

Formulation The protein was lyophilized from a solution containing 50mM histidine, 0.3M NaCl, 5mM CaCl2, 0.02% Tween 80, 20mM sucrose, pH- 6.8.

Solubility It is recommended to reconstitute the lyophilized Factor-VIII in 1ml sterile 18MΩ-cm H2O, which can then be further diluted to other aqueous solutions.

Stability Lyophilized Factor-VIII although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Factor-VIII should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
Please prevent freeze-thaw cycles.

Purity Greater than 97.0% as determined by SDS-PAGE.

Biological Activity The specific activity was found to be 6839IU/mg.

Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Synonyms	Coagulation factor VIII, Procoagulant component, Antihemophilic factor, AHF, F8, F8C, F8B, HEMA, FVIII, DXS1253E, F8 protein.
Introduction	Coagulation factor VIII participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 ａnd phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma ａnd associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
Description	Antihemophilic Facor Human Recombinant produced in CHO is a glycosylated polypeptide chain having a total amino acids of 1438 （170kd）ａnd consisting of two dimer chains 80 kD ａnd 90 kD. The Factor-VIII is purified by proprietary chromatographic techniques.
Source	CHO cells （Chinese Hamster Ovarian Cells）.
Physical Appearance	Sterile Filtered White lyophilized （freeze-dried） powder.
Formulation	The protein was lyophilized from a solution containing 50mM histidine, 0.3M NaCl, 5mM CaCl2, 0.02% Tween 80, 20mM sucrose, pH- 6.8.
Solubility	It is recommended to reconstitute the lyophilized Factor-VIII in 1ml sterile 18MΩ-cm H2O, which can then be further diluted to other aqueous solutions.
Stability	Lyophilized Factor-VIII although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Factor-VIII should be stored at 4°C between 2-7 days ａnd for future use below -18°C. Please prevent freeze-thaw cycles.
Purity	Greater than 97.0% as determined by SDS-PAGE.
Biological Activity	The specific activity was found to be 6839IU/mg.
Usage	Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.