Prospec PRO-567 Haptoglobin Human/重组人结合珠蛋白_详细资料

产品信息

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Haptoglobin Human/重组人结合珠蛋白
产品编号：PRO-567
产品规格：5μg/20μg/1mg

Synonyms Haptoglobin, HP, BP, HPA1S, MGC111141, HP2-ALPHA-2.

Introduction Haptoglobin is a glycoprotein which is synthesized in the liver ａnd circulates in the blood. Haptoglobin is produced typically by hepatocytes but also by other tissues: e.g. skin, lung, ａnd kidney. It is a positive acute phase protein that binds free hemoglobin ａnd removes it from the circulation to prevent kidney injury, ａnd iron loss following hemolysis. The haptoglobin-hemoglobin complex is subsequently removed by the reticuloendothelial system （generally the spleen）. As the reticuloendothelial system removes the haptoglobin-hemoglobin complex from the body, haptoglobin levels are reduced in hemolytic anaemias. In the course of binding hemoglobin, haptoglobin sequesters the iron inside hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis.
Haptoglobin consists of two ?- ａnd two ?-chains, connected by disulfide bonds. Three major haptoglobin phenotypes are known to exist （Hp 1-1, Hp 2-1, ａnd Hp 2-2）. Hp 1-1 is biologically the most effective in binding free hemoglobin ａnd suppressing inflammatory responses associated with free hemoglobin. Hp 2-2 is biologically the least active, ａnd Hp 2-1 is moderately active. Haptoglobin’s molecular mass ranges from 8-200 kDa.
Reduced levels can be seen in haemolysis ａnd impaired liver function. High levels are a marker for acute or chronic inflammation. Ahaptoglobinemia or hypohaptoglobinemia are caused by mutations in the haptoglobin gene and/or its regulatory regions. Haptoglobin is also linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn＇s disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson＇s disease, ａnd a reduced incidence of Plasmodium falciparum malaria.

Description Haptoglobin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing （aa. 145-405） fusion protein with His tag ａnd having a total Mw of 33 kDa （4 kDa His-tag）.

Source Escherichia Coli.

Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder.

Formulation Each mg was lyophilized with 1xPBS, 0.1% SDS ａnd 1mM DTT.

Solubility It is recommended to reconstitute the lyophilized Haptoglobin in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.

Stability Lyophilized Haptoglobin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Haptoglobin should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.

Applications 1. Positive control for Western blot
2. Antibody production
3. Protein assay.

Purity Greater than 90.0% as determined by SDS-PAGE ａnd HPLC.

Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Synonyms	Haptoglobin, HP, BP, HPA1S, MGC111141, HP2-ALPHA-2.
Introduction	Haptoglobin is a glycoprotein which is synthesized in the liver ａnd circulates in the blood. Haptoglobin is produced typically by hepatocytes but also by other tissues: e.g. skin, lung, ａnd kidney. It is a positive acute phase protein that binds free hemoglobin ａnd removes it from the circulation to prevent kidney injury, ａnd iron loss following hemolysis. The haptoglobin-hemoglobin complex is subsequently removed by the reticuloendothelial system （generally the spleen）. As the reticuloendothelial system removes the haptoglobin-hemoglobin complex from the body, haptoglobin levels are reduced in hemolytic anaemias. In the course of binding hemoglobin, haptoglobin sequesters the iron inside hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis. Haptoglobin consists of two ?- ａnd two ?-chains, connected by disulfide bonds. Three major haptoglobin phenotypes are known to exist （Hp 1-1, Hp 2-1, ａnd Hp 2-2）. Hp 1-1 is biologically the most effective in binding free hemoglobin ａnd suppressing inflammatory responses associated with free hemoglobin. Hp 2-2 is biologically the least active, ａnd Hp 2-1 is moderately active. Haptoglobin’s molecular mass ranges from 8-200 kDa. Reduced levels can be seen in haemolysis ａnd impaired liver function. High levels are a marker for acute or chronic inflammation. Ahaptoglobinemia or hypohaptoglobinemia are caused by mutations in the haptoglobin gene and/or its regulatory regions. Haptoglobin is also linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn＇s disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson＇s disease, ａnd a reduced incidence of Plasmodium falciparum malaria.
Description	Haptoglobin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing （aa. 145-405） fusion protein with His tag ａnd having a total Mw of 33 kDa （4 kDa His-tag）.
Source	Escherichia Coli.
Physical Appearance	Sterile Filtered White lyophilized （freeze-dried） powder.
Formulation	Each mg was lyophilized with 1xPBS, 0.1% SDS ａnd 1mM DTT.
Solubility	It is recommended to reconstitute the lyophilized Haptoglobin in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Stability	Lyophilized Haptoglobin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Haptoglobin should be stored at 4°C between 2-7 days ａnd for future use below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
Applications	1. Positive control for Western blot 2. Antibody production 3. Protein assay.
Purity	Greater than 90.0% as determined by SDS-PAGE ａnd HPLC.
Usage	Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.