Prospec PRO-431 LAIR1 Human/重组人白细胞结合免疫球蛋白样受体1_详细资料

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LAIR1 Human/重组人白细胞结合免疫球蛋白样受体1
产品编号：PRO-431
产品规格：5μg/20μg/1mg

Synonyms Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, CD305 antigen, LAIR1, CD305.

Introduction LAIR1 is a glycoprotein （~32kDa） expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages ａnd dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells ａnd B cells. Inhibitory receptors control the immune response to prevent lysis of cells recognized as self. Lair1 consists of a leader sequence, extracellular domain, transmembrane domain, cytoplasmic region.
LAIR1 is a member of both the immunoglobulin superfamily ａnd the leukocyte-associated inhibitory receptor family. LAIR1 maps to a region of 19q13.4 labeled the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.

Description LAIR1 Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing amino acids 105 ａnd having a molecular mass of 11.5 kDa. The extracellular domain of LAIR-1 （22-125aa） was overexpressed in E.coli, ａnd purified by using conventional chromatography techniques.

Source Escherichia Coli.

Physical Appearance Sterile filtered colorless solution.

Formulation The protein （1mg/ml） contains 20mM Tris-HCl （pH7.5） 50mM NaCl ａnd 1mM EDTA.

Stability Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Avoid multiple freeze-thaw cycles.

Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE.

Sequence MQEEDLPRPS ISAEPGTVIP LGSHVTFVCR GPVGVQTFRL ERESRSTYND TEDVSQASPSESEARFRIDS VSEGNAGPYR CIYYKPPKWS EQSDYLELLV KETSG.

Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Prospec PRO-431 LAIR1 Human/重组人白细胞结合免疫球蛋白样受体1

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Synonyms	Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, CD305 antigen, LAIR1, CD305.
Introduction	LAIR1 is a glycoprotein （~32kDa） expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages ａnd dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells ａnd B cells. Inhibitory receptors control the immune response to prevent lysis of cells recognized as self. Lair1 consists of a leader sequence, extracellular domain, transmembrane domain, cytoplasmic region. LAIR1 is a member of both the immunoglobulin superfamily ａnd the leukocyte-associated inhibitory receptor family. LAIR1 maps to a region of 19q13.4 labeled the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.
Description	LAIR1 Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing amino acids 105 ａnd having a molecular mass of 11.5 kDa. The extracellular domain of LAIR-1 （22-125aa） was overexpressed in E.coli, ａnd purified by using conventional chromatography techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile filtered colorless solution.
Formulation	The protein （1mg/ml） contains 20mM Tris-HCl （pH7.5） 50mM NaCl ａnd 1mM EDTA.
Stability	Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Avoid multiple freeze-thaw cycles.
Purity	Greater than 95.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE.
Sequence	MQEEDLPRPS ISAEPGTVIP LGSHVTFVCR GPVGVQTFRL ERESRSTYND TEDVSQASPSESEARFRIDS VSEGNAGPYR CIYYKPPKWS EQSDYLELLV KETSG.
Usage	Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.