nhibin Alpha Chain (INHA),Inhibin Alpha 【产品介绍】Inhibin alpha chain is a peptide hormone that inhibits the secretion of follitropin by the pituitary gland. Inhibins and activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition (1). Granulosa-cell tumors produce inhibin and since serum inhibin levels reflect the size of the tumor, measurements of inhibin can be used as a marker for primary as well as recurrent disease (2). In the malignant regions of tissue from men with high grade prostate cancer, the expression of the inhibin alpha-subunit gene is suppressed and was not detectable in poorly differentiated tumor cells. These results demonstrate that in contrast to ovarian granulosa cell tumors, inhibin alpha chain is not expressed in poorly differentiated prostate cancer (3). nhibin Alpha Chain (INHA),Inhibin Alpha Recommended Applications WB, FC Applications and Recommended Dilution Factors WB: 1:1000 - 2000 FC: 1:300 Species Reactivity * Human, Mouse, Rat *Cross reactivity determined by western blot only. Products Data nhibin Alpha Chain (INHA),Inhibin Alpha . Western blot analysis on (A) Hu-Adrenal gland (B) HeLa (C) Hu-placenta and (D) LNCaP lysates using anti-Inhibin alpha chain RabMAb (cat. #2623-1), dilution 1:2000. Specificity A synthetic peptide corresponding to residues near the N-terminus of human Inhibin alpha chain was used as an immunogen. 20/23 kDa bands consist of the mature alpha chain. 50/53 kDa bands are the entire proprotein. |