Catalog Number:
212-12
Synonyms:
T-cell growth factor (TCGF), Aldesleukin
Description:
IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant murine IL-2 is a 17.2 kDa protein, containing 149 amino acid residues.
AA Sequence:
PTSSSTSSST AEAQQQQQQQ QQQQQHLEQL LMDLQELLSR MENYRNLKLP RMLTFKFYLP KQATELKDLQ CLEDELGPLR HVLDLTQSKS FQLEDAENFI SNIRVTVVKL KGSDNTFECQ FDDESATVVD FLRRWIAFCQ SIISTSPQ
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 as determined by the dose dependent stimulation of murine CTLL-2 cells is < 0.2 ng/ml, corresponding to a specific activity of > 5 x 106 units/mg.
Cross Reactivity:
Human, Mouse, Leech, N/A
Research Interests:
| AIDS / HIV | | Cancer |
| Cell Culture | | Diabetes / Weight Regulation |
| Immune System | | Inflammation |
| Neurobiology | | Proliferation |
| Stem Cells & Differentiation | | Wound Healing |
| Allergy | | Transplantation |
Country of Origin:
USA