人成纤维母细胞-新生成纤维细胞是来源于中胚层的一种间充质细胞。它被广泛应用于细胞和分子生物学的研究。这主要是因为它是一种较容易培养的，耐受性较好的细胞，可应用于基因转染、显微注射等多种操作。现已证明不同部位的成纤维细胞有着本质的不同，组织里的成纤维细胞处于一种动态的平衡之中，这种平衡影响着健康，以及已愈合软组织的结构完整性。成纤维细胞分泌一种非刚性细胞外基质，其中含有I型和III型胶原质。此外纤维细胞在炎症刺激下还能分泌大量透明质酸。在创伤愈合过程中，成纤维细胞从迁移、再生表型转变为可收缩、基质聚集表型。 <2310>人纤维原细胞－成人提取于成人皮肤组
人成纤维母细胞-新生
上海义森生物科技有限公司
<2310>人纤维原细胞－成人提取于成人皮肤组织，原代冻存。每管含有细胞数>5×105 cells/ml，此细胞通过Fibronectin免疫荧光染色验证，经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增。
推荐培养基:（FM, Cat. No. 2301）
产地：San Diego,US储存：液氮
品Pai：ScienCell
运输：干冰
用途：科研
Fibroblasts are mesenchymal cells which are derived from the embryonic mesoderm. They have been used extensively for a wide range of cellular ａnd molecular studies. This is mainly because they are one of easiest types of cells to grow in culture, ａnd their durability makes them amenable to a wide variety of manipulations ranging from studies employing gene transfection to microinjection. There is good evidence that fibroblasts in different parts of the body are intrinsically different [1]. Fibroblasts within tissues are exposed to a dynamic mechnical environment, which influences the structure integrity of both healthy ａnd healing soft tissue. Fibroblasts secrete a nonrigid extracellular matrix that is rich in type I and/or type III collagen [2]. Besides, dermal fibroblasts also secrete large quantities of hyaluronan in response to inflammatory stimuli [3]. During wound healing, dermal fibroblasts switch from a migratory, repopulating phenotype to a contractile, matrix-reassembling phenotype.
HDFn from ScienCell Research Laboratories are isolated from human neonate skin. HDFn are cryopreserved at primary culture ａnd delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HDFn are characterized by their spindle morphology ａnd immunofluorescent method with antibody to fibronectin. HDFn are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast ａnd fungi. HDFn are guaranteed to further expand for 15 population doublings at the conditions provided by ScienCell Research Laboratories.
Reference
[1] Conrad, G. W., Hart, G. W., Chen, Y. （1977） Differences in vitro between fibroblast-like cells from cornea, heart, ａnd skin of embryonic chicks. J. Cell Sci. 26:119-137.
[2] Gabbiani, G., Rungger-Brandle, E., The fibroblast. In Tissue Repair ａnd Regeneration （L. E. Glynn, ed.）, pp 1-50. Handbook of Inflammation, Vol. 3. Amsterdam, Elsevier, 1981.
[3] Stair S, Carlson KW, Shuster S, Wei ET, Stern R （2004） Mystixin peptides reduce hyaluronan deposition ａnd edema formation. Eur J Pharmacol 2004 Aug 30;450（3）:291-6.
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