Lapatinib Ditosylate 技术数据:分子量(MW): 925.46 化学式: C29H26ClFN4O4S.2C7H8O3S 溶解度: DMSO 185mg/mL Water <1mg/mL Ethanol <1mg/mL 纯度: 99% 稳定性: at -20℃ 2 years CAS号: 388082-77-7, 231277-92-2 (free base), 1187538-35-7 (4-methylbenzenesulfonate)
Lapatinib Ditosylate
上海义森生物科技有限公司
| 分子量（MW）: | 925.46 |  |
|---|---|---|
| 化学式: | C29H26ClFN4O4S.2C7H8O3S | |
| 溶解度: | DMSO 185mg/mL Water <1mg/mL Ethanol <1mg/mL | |
| 纯度: | 99% | |
| 稳定性: | at -20℃ 2 years | |
| CAS号: | 388082-77-7, 231277-92-2 （free base）, 1187538-35-7 （4-methylbenzenesulfonate） |
Lapatinib Ditosylate （Tykerb） was found to have 50% inhibitory concentration （IC50） values against purified EGFR ａnd HER2 of 10.2 ａnd 9.8 nM, respectively. And IC50 >10000nM against c-Raf-1,MEK,ERK,CDK1CDK2,p38 ａnd VEGFR-2.
The IC50s for inhibition of cell growth by 72h treatment with GW2016 are 0.16μM for A431,0.12 μM for HN5,0.10 μM for BT474,0.09 μM for N87.
Lapatinib undergoes first-pass metabolism catalyzed by CYP3A4/5 ａnd does not appear to be a substrate for P-glycoprotein. [2]
Lapatinib ditosylate / Lapatinib ditosylate
Lapatinib ditosylate / Lapatinib ditosylate
Lapatinib Ditosylate (GW-572016) / Lapatinib Ditosylate (GW-572016)
Lapatinib Ditosylate (GW-572016) / Lapatinib Ditosylate (GW-572016) 388082-77-7
Lapatinib ditosylate (甲苯磺酸拉帕替尼; GW-572016 ditosylate) 是EGFR和ErbB2YZ剂，IC50分别为10.8和9.2 nM。
Lapatinib Ditosylate Hydrate 231277-92-2 (base) 388082-78-8 (ditosylate)
Lapatinib ditosylate(GW-572016 ditosylate)是EGFR和ErbB2YZ剂，IC50分别为10.8和9.2 nM。
Lapatinib Ditosylate ( Lapatinib, Di-p-Toluenesulfonate,GW-572016, GW2016, Tykerb®,Tyverb®)
Lapatinib Ditosylate
二甲苯磺酸拉帕替尼，Lapatinib Ditosylate
Lapatinib Ditosylate
ICG1029-0025MG ICG1029-Lapatinib Ditosylate
本产品信息由（上海义森生物科技有限公司）为您提供，内容包括（Lapatinib Ditosylate）的品牌、型号、技术参数、详细介绍等；如果您想了解更多关于（Lapatinib Ditosylate）的信息，请直接联系供应商，给供应商留言。若当前页面内容侵犯到您的权益，请及时告知我们，我们将马上修改或删除。
沪公网安备 31011502008050号
