PRO-331 Factor VIIa Human/重组人因子VIIa_详细资料

产品信息

PRO-331 Factor VIIa Human/重组人因子VIIa

慧嘉生物您实验身边的好伙伴
为客户提供“质量的产品”和“质的服务”
欢迎广大客户咨询，另有大量宣传海报和小礼品赠送。
网站：www.biohj.com
联系电话：
传    真：
Q Q：382603320      1284882975
邮    箱：sale@biohj.com
Factor VIIa Human/重组人因子VIIa
产品编号：PRO-331
产品规格：10μg/50μg/1mg

Synonyms Coagulation factor VII, EC 3.4.21.21, Serum prothrombin conversion accelerator, SPCA, Proconvertin, Eptacog alfa, F7.

Introduction Coagulation factor VII is a vitamin K-dependent factor which is essential for hemostasis. It circulates in the blood as a zymogen which is later converted to an active form by factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of factor VII, a heavy chain with a catalytic domain ａnd a light chain with 2 EGF-like domains are generated, ａnd the two chains are held together by a disulfide bond. The presence of factor III ａnd calcium ions further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. alternative splicing of factor VII results in 2 transcripts. Defects in coagulation factor VII can cause coagulopathy. Coagulation factor VII initiates the extrinsic pathway of blood coagulation. Minor proteolysis converts factor VII to factor VIIa by factors Xa, XIIa, IXa, or thrombin. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor ａnd calcium.

Description Factor VIIa Human Recombinant produced in BHK is a glycosylated polypeptide two-chain dimer consisting of 406 amino acids with a molecular weight of 50kD.
The Factor-VIIa is purified by proprietary chromatographic techniques.

Source BHK cells （Baby Hamster Kidney Cells）.

Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder.

Formulation The protein 1 mg/ml was lyophilized after from a sterile solution containing 4.86 mg sodium chloride, 2.45 mg calcium chloride dihydrate, 50 mg mannitol ａnd 116 μg Tween 80.

Solubility It is recommended to reconstitute the lyophilized Factor-VIIa in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.

Stability Lyophilized Factor-VIIa although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Factor-VIIa should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
Please prevent freeze-thaw cycles.

Purity Greater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE.

Biological Activity The potency per mg was tested ａnd found to be 50,000Units/mg.

Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

您可能感兴趣的产品

Synonyms	Coagulation factor VII, EC 3.4.21.21, Serum prothrombin conversion accelerator, SPCA, Proconvertin, Eptacog alfa, F7.
Introduction	Coagulation factor VII is a vitamin K-dependent factor which is essential for hemostasis. It circulates in the blood as a zymogen which is later converted to an active form by factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of factor VII, a heavy chain with a catalytic domain ａnd a light chain with 2 EGF-like domains are generated, ａnd the two chains are held together by a disulfide bond. The presence of factor III ａnd calcium ions further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. alternative splicing of factor VII results in 2 transcripts. Defects in coagulation factor VII can cause coagulopathy. Coagulation factor VII initiates the extrinsic pathway of blood coagulation. Minor proteolysis converts factor VII to factor VIIa by factors Xa, XIIa, IXa, or thrombin. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor ａnd calcium.
Description	Factor VIIa Human Recombinant produced in BHK is a glycosylated polypeptide two-chain dimer consisting of 406 amino acids with a molecular weight of 50kD. The Factor-VIIa is purified by proprietary chromatographic techniques.
Source	BHK cells （Baby Hamster Kidney Cells）.
Physical Appearance	Sterile Filtered White lyophilized （freeze-dried） powder.
Formulation	The protein 1 mg/ml was lyophilized after from a sterile solution containing 4.86 mg sodium chloride, 2.45 mg calcium chloride dihydrate, 50 mg mannitol ａnd 116 μg Tween 80.
Solubility	It is recommended to reconstitute the lyophilized Factor-VIIa in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Stability	Lyophilized Factor-VIIa although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Factor-VIIa should be stored at 4°C between 2-7 days ａnd for future use below -18°C. Please prevent freeze-thaw cycles.
Purity	Greater than 98.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE.
Biological Activity	The potency per mg was tested ａnd found to be 50,000Units/mg.
Usage	Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.