PRO-297 FHIT Human, GST/重组人精细组氨酸三元组, GST_详细资料

产品信息

PRO-297 FHIT Human, GST/重组人精细组氨酸三元组, GST

慧嘉生物您实验身边的好伙伴
为客户提供“质量的产品”和“质的服务”
欢迎广大客户咨询，另有大量宣传海报和小礼品赠送。
网站：www.biohj.com
联系电话：
传    真：
Q Q：382603320      1284882975
邮    箱：sale@biohj.com
FHIT Human, GST/重组人精细组氨酸三元组, GST
产品编号：PRO-297
产品规格：2μg/5μg/10μg

Synonyms Bis（5＇-adenosyl）-triphosphatase, EC 3.6.1.29, Diadenosine 5＇,5＇＇＇-P1,P3-triphosphate hydrolase, Dinucleosidetriphosphatase, AP3A hydrolase, AP3Aase, Fragile histidine triad protein, FHIT, FRA3B.

Introduction FHIT is a member of the histidine triad gene family. FHIT gene encodes a diadenosine 5＇,5＇＇＇-P1,P3-triphosphate hydrolase involved in purine metabolism. FHIT gene includes the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations ａnd abnormal transcripts of this gene. The FHIT protein is a tumor suppressor with reduced or no expression in numerous types of cancer. FHIT may also act as a tumor suppressor in normal cells. alterations ａnd deletions of the FHIT （Fragile Histidine Triad） gene are strongly linked to the genesis ａnd establishment of human tumors of the lung, cervix, breast, colon, stomach, ａnd pancreas. The expression of FHIT is more often lost in cancers of individuals with familial mutations causing deficiency in DNA repair genes such as BRCA1, BRCA2 ａnd MSH2. In vitro FHIT functions as a hydrolase that cleaves diadenosine triphosphate （Ap3A） to ADP ａnd AMP. The FHIT -Ap3A enzyme-substrate complex seems to be the tumor suppressor signal. The restoration of FHIT expression in FHIT -deficient cancer cells leads to apoptosis, involving the intrinsic caspase pathway, in cancer-derived cells ａnd in tumor xenografts.

Description FHIT Human Recombinant full length protein expressed in E.coli, shows a 43 kDa band on SDS-PAGE.
The FHIT is fused to GST-Tag ａnd purified by proprietary chromatographic techniques.

Source Escherichia Coli.

Physical Appearance Sterile Filtered clear solution.

Formulation FHIT in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol.

Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles.

Applications ? ELISA
? Inhibition Assays
? Western Blotting.

Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

您可能感兴趣的产品

Synonyms	Bis（5＇-adenosyl）-triphosphatase, EC 3.6.1.29, Diadenosine 5＇,5＇＇＇-P1,P3-triphosphate hydrolase, Dinucleosidetriphosphatase, AP3A hydrolase, AP3Aase, Fragile histidine triad protein, FHIT, FRA3B.
Introduction	FHIT is a member of the histidine triad gene family. FHIT gene encodes a diadenosine 5＇,5＇＇＇-P1,P3-triphosphate hydrolase involved in purine metabolism. FHIT gene includes the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations ａnd abnormal transcripts of this gene. The FHIT protein is a tumor suppressor with reduced or no expression in numerous types of cancer. FHIT may also act as a tumor suppressor in normal cells. alterations ａnd deletions of the FHIT （Fragile Histidine Triad） gene are strongly linked to the genesis ａnd establishment of human tumors of the lung, cervix, breast, colon, stomach, ａnd pancreas. The expression of FHIT is more often lost in cancers of individuals with familial mutations causing deficiency in DNA repair genes such as BRCA1, BRCA2 ａnd MSH2. In vitro FHIT functions as a hydrolase that cleaves diadenosine triphosphate （Ap3A） to ADP ａnd AMP. The FHIT -Ap3A enzyme-substrate complex seems to be the tumor suppressor signal. The restoration of FHIT expression in FHIT -deficient cancer cells leads to apoptosis, involving the intrinsic caspase pathway, in cancer-derived cells ａnd in tumor xenografts.
Description	FHIT Human Recombinant full length protein expressed in E.coli, shows a 43 kDa band on SDS-PAGE. The FHIT is fused to GST-Tag ａnd purified by proprietary chromatographic techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile Filtered clear solution.
Formulation	FHIT in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol.
Stability	Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
Applications	? ELISA ? Inhibition Assays ? Western Blotting.
Usage	Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.