PRO-722 PEBP1 Human/重组人磷脂酰乙醇胺结合蛋白1_详细资料

产品信息

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厦门慧嘉生物长期专业销售PRO-722 PEBP1 Human/重组人磷脂酰乙醇胺结合蛋白1 ASSAY Santa Abcam Cst jackson Pierce Sigma Amresco Qiagen Cayman abnova millipore invitrogen merk ebioscience prospec peprotech细胞因子特价。等生物试剂产品。实验为大，诚信经营，为客户提供“质量的产品”和“质的服务"QQ: 1193953234 1048735792 或登陆（向客服人员索取原版说明书） http://www.biohj.com 欢迎广大老师来询！

PEBP1 Human/重组人磷脂酰乙醇胺结合蛋白1
产品编号：PRO-722
产品规格：10μg/50μg/1mg

Synonyms Phosphatidylethanolamine-binding protein 1, Prostatic-binding protein, HCNPpp, Neuropolypeptide h3, Raf kinase inhibitor protein, PEBP-1, RKIP, PEBP1, PBP, PEBP, HCNP.

Introduction PEBP1 （Phosphatidylethanolamine binding protein 1） belongs to the phosphatidylethanolamine-binding protein family ａnd a serine protease inhibitor that inhibits thrombin, neuropsin. PEBP1 plays a key modulatory part in several protein kinase signaling cascades. PKC phosphorylates PEBP1, resulting in the release of Raf-1 ａnd activation of MEK ａnd ERK. PEBP1 is expressed in many tissues ａnd implicated in the regulation of such physiological processes as membrane biosynthesis, spermatogenesis, neural development, ａnd metastasis suppression.
PEBP1 binds ATP, opioids ａnd phosphatidylethanolamine, however it has lower affinity for phosphatidylinositol ａnd phosphatidylcholine. PEBP1 may also be involved in the function of the presynaptic cholinergic neurons of the CNS. PEBP1 increases the production of choline acetyltransferase although not acetylcholinesterase. Furtheremore, PEBP1 functions in potentially sequestering toxic compounds, including locostatin which may have harmful effects on cells.
Loss of PEBP1 expression may have a significant role as prognostic marker in Gastrointestinal stromal tumors. In addition, PEBP1 is found differentially expressed in the Wernicke＇s Area from schizophrenia patients. PEBP1 is also, an invasion suppressor protein in nasopharyngeal carcinoma.

Description PEBP1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 187 amino acids （1-187 a.a.）ａnd having a molecular mass of 21kDa.
The PEBP1 is purified by proprietary chromatographic techniques.

Source Escherichia Coli.

Physical Appearance Sterile Filtered colorless solution.

Formulation The PEBP1 protein solution contains 20mM Tris-HCl buffer （pH8.0）, 1mM DTT ａnd 10% glycerol.

Stability PEBP1 although stable 4°C for 4 weeks, should be stored desiccated below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.

Amino Acid Sequence MPVDLSKWSG PLSLQEVDEQ PQHPLHVTYA GAAVDELGKV LTPTQVKNRP TSISWDGLDS GKLYTLVLTD PDAPSRKDPK YREWHHFLVV NMKGNDISSG TVLSDYVGSG PPKGTGLHRY VWLVYEQDRP LKCDEPILSN RSGDHRGKFK VASFRKKYEL RAPVAGTCYQ AEWDDYVPKL YEQLSGK.

Purity Greater than 95.0% as determined by SDS-PAGE.

Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Synonyms	Phosphatidylethanolamine-binding protein 1, Prostatic-binding protein, HCNPpp, Neuropolypeptide h3, Raf kinase inhibitor protein, PEBP-1, RKIP, PEBP1, PBP, PEBP, HCNP.
Introduction	PEBP1 （Phosphatidylethanolamine binding protein 1） belongs to the phosphatidylethanolamine-binding protein family ａnd a serine protease inhibitor that inhibits thrombin, neuropsin. PEBP1 plays a key modulatory part in several protein kinase signaling cascades. PKC phosphorylates PEBP1, resulting in the release of Raf-1 ａnd activation of MEK ａnd ERK. PEBP1 is expressed in many tissues ａnd implicated in the regulation of such physiological processes as membrane biosynthesis, spermatogenesis, neural development, ａnd metastasis suppression. PEBP1 binds ATP, opioids ａnd phosphatidylethanolamine, however it has lower affinity for phosphatidylinositol ａnd phosphatidylcholine. PEBP1 may also be involved in the function of the presynaptic cholinergic neurons of the CNS. PEBP1 increases the production of choline acetyltransferase although not acetylcholinesterase. Furtheremore, PEBP1 functions in potentially sequestering toxic compounds, including locostatin which may have harmful effects on cells. Loss of PEBP1 expression may have a significant role as prognostic marker in Gastrointestinal stromal tumors. In addition, PEBP1 is found differentially expressed in the Wernicke＇s Area from schizophrenia patients. PEBP1 is also, an invasion suppressor protein in nasopharyngeal carcinoma.
Description	PEBP1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 187 amino acids （1-187 a.a.）ａnd having a molecular mass of 21kDa. The PEBP1 is purified by proprietary chromatographic techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile Filtered colorless solution.
Formulation	The PEBP1 protein solution contains 20mM Tris-HCl buffer （pH8.0）, 1mM DTT ａnd 10% glycerol.
Stability	PEBP1 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
Amino Acid Sequence	MPVDLSKWSG PLSLQEVDEQ PQHPLHVTYA GAAVDELGKV LTPTQVKNRP TSISWDGLDS GKLYTLVLTD PDAPSRKDPK YREWHHFLVV NMKGNDISSG TVLSDYVGSG PPKGTGLHRY VWLVYEQDRP LKCDEPILSN RSGDHRGKFK VASFRKKYEL RAPVAGTCYQ AEWDDYVPKL YEQLSGK.
Purity	Greater than 95.0% as determined by SDS-PAGE.
Usage	ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.