PRO-558 Haptoglobin Human/重组人结合珠蛋白_详细资料

产品信息

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厦门慧嘉生物长期专业销售PRO-558 Haptoglobin Human/重组人结合珠蛋白 Santa Abcam Cst jackson Pierce Sigma Amresco Qiagen Cayman abnova millipore invitrogen merk ebioscience prospec peprotech细胞因子特价。等生物试剂产品。实验为大，诚信经营，为客户提供“质量的产品”和“质的服务"QQ: 1193953234 1048735792 或登陆（向客服人员索取原版说明书） http://www.biohj.com 欢迎广大老师来询！

Haptoglobin Human/重组人结合珠蛋白
产品编号：PRO-558
产品规格：200μg/1mg/10mg

Synonyms Haptoglobin, HP, BP, HPA1S, MGC111141, HP2-ALPHA-2.

Introduction Haptoglobin is a glycoprotein which is synthesized in the liver ａnd circulates in the blood. Haptoglobin is produced typically by hepatocytes but also by other tissues: e.g. skin, lung, ａnd kidney. It is a positive acute phase protein that binds free hemoglobin ａnd removes it from the circulation to prevent kidney injury, ａnd iron loss following hemolysis. The haptoglobin-hemoglobin complex is subsequently removed by the reticuloendothelial system （generally the spleen）. As the reticuloendothelial system removes the haptoglobin-hemoglobin complex from the body, haptoglobin levels are reduced in hemolytic anaemias. In the course of binding hemoglobin, haptoglobin sequesters the iron inside hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis.
Haptoglobin consists of two ?- ａnd two ?-chains, connected by disulfide bonds. Three major haptoglobin phenotypes are known to exist （Hp 1-1, Hp 2-1, ａnd Hp 2-2）. Hp 1-1 is biologically the most effective in binding free hemoglobin ａnd suppressing inflammatory responses associated with free hemoglobin. Hp 2-2 is biologically the least active, ａnd Hp 2-1 is moderately active. Haptoglobin’s molecular mass ranges from 8-200 kDa.
Reduced levels can be seen in haemolysis ａnd impaired liver function. High levels are a marker for acute or chronic inflammation. Ahaptoglobinemia or hypohaptoglobinemia are caused by mutations in the haptoglobin gene and/or its regulatory regions. Haptoglobin is also linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn＇s disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson＇s disease, ａnd a reduced incidence of Plasmodium falciparum malaria.

Description Human Haptoglobin produced from pooled human plasma.

Source Pooled human plasma.

Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder.

Formulation Lyophilized from 0.02M NH4HCO3. May contain traces of buffer salts.

Stability Human Hapto although stable at room temperature for 3 weeks, should be stored between 2-8°C.

Purity Greater than 96.0%.

Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Synonyms	Haptoglobin, HP, BP, HPA1S, MGC111141, HP2-ALPHA-2.
Introduction	Haptoglobin is a glycoprotein which is synthesized in the liver ａnd circulates in the blood. Haptoglobin is produced typically by hepatocytes but also by other tissues: e.g. skin, lung, ａnd kidney. It is a positive acute phase protein that binds free hemoglobin ａnd removes it from the circulation to prevent kidney injury, ａnd iron loss following hemolysis. The haptoglobin-hemoglobin complex is subsequently removed by the reticuloendothelial system （generally the spleen）. As the reticuloendothelial system removes the haptoglobin-hemoglobin complex from the body, haptoglobin levels are reduced in hemolytic anaemias. In the course of binding hemoglobin, haptoglobin sequesters the iron inside hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis. Haptoglobin consists of two ?- ａnd two ?-chains, connected by disulfide bonds. Three major haptoglobin phenotypes are known to exist （Hp 1-1, Hp 2-1, ａnd Hp 2-2）. Hp 1-1 is biologically the most effective in binding free hemoglobin ａnd suppressing inflammatory responses associated with free hemoglobin. Hp 2-2 is biologically the least active, ａnd Hp 2-1 is moderately active. Haptoglobin’s molecular mass ranges from 8-200 kDa. Reduced levels can be seen in haemolysis ａnd impaired liver function. High levels are a marker for acute or chronic inflammation. Ahaptoglobinemia or hypohaptoglobinemia are caused by mutations in the haptoglobin gene and/or its regulatory regions. Haptoglobin is also linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn＇s disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson＇s disease, ａnd a reduced incidence of Plasmodium falciparum malaria.
Description	Human Haptoglobin produced from pooled human plasma.
Source	Pooled human plasma.
Physical Appearance	Sterile Filtered White lyophilized （freeze-dried） powder.
Formulation	Lyophilized from 0.02M NH4HCO3. May contain traces of buffer salts.
Stability	Human Hapto although stable at room temperature for 3 weeks, should be stored between 2-8°C.
Purity	Greater than 96.0%.
Usage	Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.