C6019 Interferes with Protein Synthesis_详细资料

产品信息 品牌 sigma 货号 C6019 规格克霉唑供货周期一周 Interferes with Protein Synthesis Protein synthesis is a complex, multi-step process involving many enzymes as well as conformational alignment. Aminoglycosides are antibiotics that block bacterial protein synthesis interfere with the processes at the 30S subunit or 50S subunit of the 70S bacterial ribosome. The primary steps in the process that are inhibited are: formation of the 30S initiation complex (made up of mRNA, the 30S ribosomal subunit, and formyl-methionyl-transfer RNA) formation of the 70S ribosome by the 30S initiation complex and the 50S ribosome elongation process of assembling amino acids into a polypeptide Tetracyclines, including doxycycline, prevent the binding of aminoacyl-tRNA by blocking the A (aminoacyl) site of the 30S ribosome. They are capable of inhibiting protein synthesis in both 70S and 80S (eukaryotic) ribosomes, but they preferentially bind to bacterial ribosomes due to structural differences in RNA subunits. Tetracyclines also exploit the bacterial transport system and significantly increase the concentration of the antibiotic within the cell than the environmental concentration. Aminoglycoside antibiotics have an affinity for the 30S ribosome subunit. Streptomycin, one of the most commonly used aminoglycosides, interferes with the creation of the 30S initiation complex. Kanamycin and tobramycin also bind to the 30S ribosome and block the formation of the larger 70S initiation complex. Erythromycin, a macrolide, binds to the 23S rRNA component of the 50S ribosome and interferes with the assembly of 50S subunits. Erythromycin, roxithromycin, and clarithromycin all prevent elongation at the transpeptidation step of synthesis by blocking the 50S polypeptide export tunnel. Elongation is prematurely terminated after a small peptide has been formed, but cannot move past the macrolide roadblock. Peptidyl transferase is a key enzyme involved in translocation, the final step in the peptide elongation cycle. Lincomycin and clindamycin are specific inhibitors of peptidyl transferase. Puromycin does not inhibit the enzymatic process, but instead competes by acting as an analog of the 3′-terminal end of aminoacyl-tRNA, disrupting synthesis and causing premature chain termination. Hygromycin B is an aminoglycoside that specifically binds to a single site within the 30S subunit in a region that contains the A, P, and E sites of tRNA. It has been theorized that this binding distorts the ribosomal A site and may be the cause of hygromycin B’s ability to induce misreading of aminoacyl-tRNAs as well as prevent the translocation of peptide elongation. Product # Description Add to Cart A1720 G 418 二硫 powder, BioReagent, suitable for cell culture 价格 A2324 Amikacin sulfate salt aminoglycoside antibiotic 价格 C5269 Clindamycin hydrochloride lincosamide antibiotic 价格 L6004 Lincomycin hydrochloride ≥90% (TLC) 价格 62143 Lincomycin hydrochloride ≥95.0% (TLC) 价格 S1442 Sordarin sodium salt 钠盐 from Sordaria araneosa, ≥98% (HPLC), solid 价格 M9511 二甲胺四环素盐酸盐 powder 价格 C6019 克霉唑 价格 33894 克霉唑 VETRANAL^™, analytical standard 价格 R3501 利福平 ≥97% (HPLC), powder 价格 N7878 呋喃妥因 crystalline 价格 46502 呋喃妥因 VETRANAL^™, analytical standard 价格 S4014 壮观霉素二盐五水合物 powder, BioReagent, suitable for cell culture 价格 D9891 多西环素单盐酸半乙醇半水合物 ≥98% (HPLC) 价格 G1914 庆大霉素硫酸酯 meets USP testing specifications, powder 价格 N6386 新霉素三硫水合物 powder, BioReagent, suitable for cell culture 价格 F7129 5-氟胞嘧啶 nucleoside analog 价格 E6376 红霉素 potency: ≥850 μg per mg 价格

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