50mg 醋酸地塞美松/Dexamethasone Acetate_详细资料

产品信息

品牌 USP/美国货号 S3124 规格 50mg 供货周期现货主要用途科研

醋酸地塞美松/Dexamethasone Acetate
化学数据
分子量 434.5 稳定性 3年 -20°C粉状
化学式
C24H31FO6
-- -- --
CAS号 1177-87-3 别名 NSC 39471
Solubility (25°C) * 体外 DMSO 87 mg/mL (200.23 mM)
Ethanol 20 mg/mL (46.02 mM)
Water Insoluble
体内
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 16α-Methyl-9α-fluoroprednisolone 21-acetate
制备储备液
浓度溶剂体积(DMSO)质量 1 mg 5 mg 10 mg
1 mM 2.3015 mL 11.5075 mL 23.0150 mL
5 mM 0.4603 mL 2.3015 mL 4.6030 mL
10 mM 0.2301 mL 1.1507 mL 2.3015 mL
50 mM 0.0460 mL 0.2301 mL 0.4603 mL
生物活性
产品描述 Dexamethasone 是一种有效的糖皮质激素类合成物，属于类固醇药物。Dexamethasone用于很多炎症和自身免疫病的ZL，例如风湿性关节炎和支气管痉挛。接受化疗的癌症病人服用dexamethasone去抵消部分化疗带来的副作用。Dexamethasone 也用在诊断方面，利用它能YZ垂体一肾上腺轴特性。
靶点
interleukin receptor [1]
体外研究 Dexamethasone用于很多炎症和自身免疫病的ZL，例如风湿性关节炎和支气管痉挛。接受化疗的癌症病人服用dexamethasone去抵消部分化疗带来的副作用。Dexamethasone 也用在诊断方面，利用它能YZ垂体一肾上腺轴特性。
体内研究
临床实验
特征

参考
Blanco FJ, et al. J Rheumatol, 1999, 26(6), 1366-1373.
Yamamoto K, et al. FEBS Lett, 2000, 465(2-3), 103-106.
[3] Rickard DJ, et al. Dev Biol, 1994, 161(1), 218-228.
[4] Nagy P, et al. Hepatology, 1998, 28(2), 423-429.
[5] Kim JB, et al. Brain Res, 2004, 1027(1-2), 1-10.
[6] Wu CY, et al. J Immunol. 1998, 161(6), 2723-2730.
客户使用selleck产品的实验数据
数据来源于[Oncogene, 2013, 32, 1316-29]

Dexamethasone and largazole cooperate to suppress invasion and to restore E-cadherin localization to the cell peripher y. ( a) Phase contrast micrographs showing morphological changes in MDA-MB-231 cells induced by E-cadherin expression combined with 100 nM dexamethasone and 10 nM largazole treatments. Insets show the cells at higher magnification. (b ) Fluorescence (E-Cad-GFP) or immunofluorescence microscopy (g -catenin (g-Cat.)) of 231/E-Cad-GFP cells treated for 72 h with vehicle (Control), 100 n M dexamethasone, 10 nM largazole or 100 nM dexamethasone + 10 nM largazole (Dex. + Larg.). (c ) Invasion assays were per formed with the indicated cell lines treated for 72 h with or without 100 nM dexamethasone + 10 nM largazole using modified Boyden chambers impregnated with matrigel. The results are presented as the average number of cells that invaded through the membrane per field s.d. of five randomly chosen fields, and are representative of three independently per formed experiments.

数据来源于[Oncogene, 2013, 32, 1316-29]

(d) BT549 cells were treated and analyzed by immunofluorescence microscopy as in Figure b. (e) BT549 cells were treated as described in Figure b and analyzed for invasion as in Figure 3c. (f) Quantitation of junctional E-cadherin staining of the indicated cell lines treated with DMSO vehicle or Dex.+ Larg. as described in Figure b. Results are presented as the mean of analyses of three different fields of cells for each sample±s.d. Statistical significance was assessed using Student’s t -test.

如果需要长期保存，请于零下二十度低温保存。
禁止用于人体及ZL！
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C ，YZ剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。
醋酸地塞美松/Dexamethasone Acetate

分子量	434.5	稳定性	3年 -20°C粉状
化学式	C24H31FO6	-- -- --
CAS号	1177-87-3	别名	NSC 39471
Solubility (25°C) *	体外	DMSO	87 mg/mL (200.23 mM)
Ethanol	20 mg/mL (46.02 mM)
Water	Insoluble
体内
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名	16α-Methyl-9α-fluoroprednisolone 21-acetate

浓度溶剂体积(DMSO)质量	1 mg	5 mg	10 mg
1 mM	2.3015 mL	11.5075 mL	23.0150 mL
5 mM	0.4603 mL	2.3015 mL	4.6030 mL
10 mM	0.2301 mL	1.1507 mL	2.3015 mL
50 mM	0.0460 mL	0.2301 mL	0.4603 mL

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