瑞禧生物 纳米金血液X射线造影剂CT造影

纳米金血液X射线造影剂CT造影

纳米金血液X射线造影剂CT造影

西安瑞禧生物科技有限公司可以提供一种用于血管CT成像造影的产品，该产品是一种在有机壳修饰的，使得金的浓度可以高达200mg/ml, 并有非常低的活体毒性，该产品是一种新型的X射线造影剂。

该产品在血液停留时间长、适合于任何造影剂，易于成像等特点。

产品信息如下：

Product Information and Instructions Product：

Name: AuroVist™-15nm Gold Nanoparticle X-ray Contrast Agent

Catalog Number: 1115

Appearance: Red Liquid

Quantity: 40 mg Au in the form of biocompatible 15 nm gold nanoparticles

Introduction

AuroVist™1 is a novel nanotechnology contrast agent based on gold nanoparticles, the first of its kind to be commercially available. AuroVist™ enables greatly enhanced X-ray imaging of blood vessels, tumors, and other biological systems and organs. AuroVist™-15 nm consists of gold nanoparticles with a core diameter of 15 nm, stabilized with a highly water soluble organic shell. This makes them useable at high concentrations (up to at least 200 mg Au/cc) and well tolerated by animals even at high concentrations (LD50 > 5 g Au/kg). Some of the significant unique features and advantages of AuroVist™-15 nm include:

• Longer blood residence time than iodine agents (~15 hr blood half-life).

• High Contrast (>1,000 HU initial blood contrast; 40 mg in a 20g mouse).

• Does not clear through kidneys (for kidney imaging use AuroVist™-1.9nm, #1102).

• Low toxicity (LD50> 5 g Au/kg).

• Can achieve higher contrast than standard iodine agents (Gold absorbs ~3 times more than an equal weight of iodine at 20 and 100 keV).

• Low osmolality, even at high concentrations.

• Low viscosity, similar to water; easy to inject with minimal trauma, even into small blood vessels.

• Can be imaged using standard MicroCT, clinical CT, planar X-ray, or mammography.

• Enhances radiotherapy dose.2

It is particularly useful for MicroCT animal imaging, such as in vivo vascular casting,3 studies of tumors, stroke, atherosclerosis and other vascular conditions

Contents：

Each vial of AuroVist™-15 nm contains 40 mg of gold in the form of 15 nm gold nanoparticles (note this is the weight of gold metal, and does not include the coordinated ligand shell around the gold core). It is supplied at a concentration of 200 mg Au/mL in 0.2 mL phosphate buffered saline (PBS: 20 mM sodium phosphate with 150 mM sodium chloride, pH 7.4), filtered through a 0.22 µm filter.

Physical Properties：

The 15 nm gold nanoparticles are red in color and soluble in aqueous solutions. They may be dried and dissolved in some organic solvents. For purification or exchange into other solvents, they may be centrifuged: they form a pellet when spun on a tabletop Eppendorf microfuge at 16,000 x g for 12 minutes.

Storage：

This product is shipped at ambient temperature. Upon receipt, the AuroVist™-15 nm gold nanoparticle solution should be stored at 4°C.

以上资料源于西安瑞禧生物科技有限公司

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