广州创仑 HER-2/neu基因检测试剂盒 荧光原位杂交法

HER-2/neu基因检测试剂盒 荧光原位杂交法

广州健仑生物科技有限公司

我司还有很多荧光原位杂交系列检测试剂盒以及各种FISH基因探针和染色体探针等，。

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mob： 杨    

  C-erbB-2和Her-2人类基因是因其与逆转录病毒V—erbB-2相似而被发现。之后Coussens L及Schechte AL等对Neu，Her-2，C-erbB-2进行测序及染色体定位分析，证明他们是同一基因。

  人类该基因定位于染色体17q12，其编码产物为185kD的跨膜精蛋白p185，由1255个氨基酸组成，720—987位属于酪氨酸激酶区。Her-2/neu蛋白是具有酪氨酸蛋白激酶活性跨膜糖蛋白，是EGFR家族成员之一。

  Her-2/neu蛋白由胞外的配体结合区、单链跨膜区及胞内的蛋白酪氨酸激酶区三部分组成，由于目前尚未发现能与Her-2/neu蛋白直接结合的配体．其主要通过与家族中其他成员包括EGFR(HERl/erbBI)，HER3/erbB3。HER4/erbB4形成异二聚体而与各自的配体结合。Her-2/neu蛋白常为异二聚体伴侣，且活性常强于其它异二聚体。当与配体结合后，主要通过引起受体二聚化及胞浆内酪氨酸激酶区的自身磷酸化．激活酪氨酸激酶的活性。

  现已证实，HRE-2的过度表达可潜在激活EGFR的信号通路，同时可促进EGFR介导的转化和肿瘤的发生。HER-2/neu基因检测试剂盒 荧光原位杂交法

我司还提供：登革热，黄热病，基肯孔热，西尼罗河，立次克体，无形体，蜱虫，恙虫，锥虫，利什曼原虫，RK39, 汉坦病毒，乙脑，森林脑炎，寨卡病毒 ，H7N9 ,流感，霍乱，军团菌，结核，诺如病毒，轮状病毒，炭疽，O157，葡萄球菌 ，流行性出血热，伤寒杆菌，志贺氏菌检测试剂,！

 以下是我司出售的部分FISH产品：

Her-2/neu protein mediated signal transduction pathways include Ras/Raf/ mitogen activated protein kinase (MAPK) pathway, phosphatidylinositol.3 hydroxyl kinase (P13K) /Akt pathway, signal transduction and transcriptional activation (STAT) pathway, and PLC pathway. 2 the expression and influencing factors of Her-2/neu protein in gastric cancer. Her-2/neu protein is usually expressed only in the fetal stage, and it is expressed in a small number of tissues only after adult. However, it is overexpressed in many kinds of human tumors, such as breast cancer, ovarian cancer, lung adenocarcinoma, primary renal cell carcinoma and endometrial carcinoma. On the gastric cancer cells, the Her-2/neu protein is mainly located on the cell membrane, and a small amount is expressed in the cytoplasm. In gastric cancer, Her-2/neu gene amplification and RNA and protein overexpression were common, but not detected in all non gastric cancer tissues, indicating that Her-2/neu protein plays an important role in the occurrence, development and invasive metastasis of gastric cancer.