peprotech Human TGF-beta3

peprotech Human TGF-beta3
产品编号：

AF-100-36E

别名：

Transforming Growth Factor-β3

转化生长因子β

peprotech Human TGF-beta3
描述：

The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and would healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown but its expression pattern suggests a role in the regulation of certain development processes. Recombinant TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond. Manufactured using all non-animal reagents.

三哺乳动物亚型TGF-ββ，TGF-ββ1，β2，β3，信号通过相同的受体具有类似的生物学效应。它们是多功能的细胞因子，调节细胞增殖，生长，分化和运动，以及细胞外基质的合成和沉积。它们参与了各种生理过程，包括胚胎发育、组织重塑和愈合。它们被分泌主要是作为潜在的复合物，它被存储在细胞表面和细胞外基质中。生物活性释放TGF-β亚型β从潜在的复杂的涉及到蛋白质如血小板反应蛋白的构象变化的复杂和/或诱导蛋白水解处理。生理作用，TGF-ββ3仍然是未知的但其表达模式表明，在一定的发展过程的调控作用。β重组TGF-β3是一个25 kDa蛋白由两个完全相同的112个氨基酸的多肽链由一个单一的二硫键连接。使用所有非动物试

氨基酸序列：

ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS

aldtnycfrn leenccvrpl yidfrqdlgw kwvhepkgyy anfcsgy lrsadtthst vlglyntlnp easaspccvp qdlepltily yvgrtpkveq lsnmvvksck CS

来源：

E.coli

大肠杆菌

纯度：

Greater than 98% by SDS-PAGE gel and HPLC analyses.

大于98%的SDS-PAGE凝胶电泳和GX液相色谱分析。

生物活性：

Determined by TGF-β3’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The expected is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥2 x 107 units/mg.

由TGF-ββ3能够YZ小鼠HT-2细胞小鼠IL-4依赖性增殖。预计≤为0.05毫微克/毫升，对应于一个特定的≥2×107单位/毫克的活性

上海江林生物拥有自己强大的细胞库，产品种属众多。另外公司长期经营ELISA试剂盒、生化试剂、胎牛血清、细胞株、细胞因子、标准品、MGB探针及其他技术实验服务等。价格实惠，质量保证。产品价格及说明书和其他详细信息请直接与我们。

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