开关相关蛋白70抗体

开关相关蛋白70抗体

英文名称 SWAP70
中文名称 开关相关蛋白70抗体
别    名 KIAA0640; 70kDa; AV235546; FLJ39540; HSPC321; SWA 70 protein; SWAP 70; SWAP switching B-cell complex 70kDa subunit; SWAP-70; SWAP70; Switch associated protein 70; Switch-associated protein 70; SWP70_HUMAN.
  
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  免疫学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 69kDa
细胞定位 细胞浆 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SWAP70
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the
PubMed PubMed
产品介绍 Function:
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.

Subcellular Location:
Cytoplasm. Cell membrane. Nucleus. Cell projection > lamellipodium. In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.

Tissue Specificity:
Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).

Post-translational modifications:
Tyrosine-phosphorylated.xy-9109R    MAP4K6 丝裂原活化蛋白激酶MAP4K6抗体
xy-0266R    MAP65拟南芥MAP65蛋白抗体
xy-11201R    Musashi 1神经干细胞RNA结合蛋白Musashi1抗体
xy-11179R    MAdCAM1粘膜细胞粘附分子1抗体
xy-4943R    MPO髓过氧化物酶抗体
xy-11352R    MAGI1膜相关鸟苷酸反转激酶1抗体
xy-11353R    Munc13 神经突触前膜胞内蛋白13抗体
xy-11322R    Membralin高度保守基因相关蛋白Membralin抗体
xy-11320R    MNX1运动神经元及同源蛋白1抗体
xy-11184R    MOBP少突胶质细胞髓鞘相关蛋白抗体
xy-11189R    MRCK alphaCDC42结合蛋白激酶α抗体（MRCKα）
xy-1047R    MyD88髓样分化蛋白抗体
xy-0337R    Myelin Protein Zero外周髓磷脂P0蛋白/P0蛋白抗体
xy-0027R    Melatonin Receptor 1A褪黑素受体1A/松果体素受体1A抗体
xy-3550R    Myogenin肌细胞生成素抗体
xy-3296R    Phospho-Myt1(Ser83)磷酸化髓鞘转录因子1抗体
xy-3503R    Mre11DNA损伤关键蛋白Mre11抗体
xy-3293R    Phospho-Mre11 (Ser676)磷酸化DNA损伤关键蛋白Mre11抗体
xy-3504R    MST1蛋白激酶MST抗体
xy-3294R    Phospho-Mst1(Thr183) + Mst2(Thr180)磷酸化蛋白激酶MST抗体
xy-3295R    Phospho-MYL(Ser19)磷酸化肌球蛋白轻链2抗体
xy-3505R    Myt1髓鞘转录因子1抗体
xy-1352R    MCL1髓样细胞白血病-1抗体
xy-1369R    MAP2微管相关蛋白2抗体
xy-9470R    MEF2B肌细胞增强因子2B抗体
xy-9471R    MESP1心血管发育中胚层相关蛋白1抗体
xy-9440R    MTA2转移相关蛋白2抗体
xy-9375R    MYCBP2MYC结合蛋白2抗体
xy-9314R    MAP7D1精氨酸/脯氨酸富含卷曲蛋白1抗体
xy-9313R    MAP-9微管相关蛋白9抗体
xy-9315R    MKLP1有丝分裂驱动蛋白样1抗体
xy-1061R    Myeloperoxidase/c-ANCA 髓过氧化物酶抗中性粒细胞胞质IgG抗体