拓扑异构酶相关功能蛋白4-2抗体

拓扑异构酶相关功能蛋白4-2抗体

英文名称 TRF4-2
中文名称 拓扑异构酶相关功能蛋白4-2抗体
别    名 PAP-associated domain-containing protein 5; Terminal uridylyltransferase 3; Topoisomerase related function protein 4-2; TRF4-2; PAPD5_HUMAN; TUTase 3.
  
说 明 书 0.2ml  
研究领域 转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRF4-2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion

Function:
Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion.

Subunit:
Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase

Subcellular Location:
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xy-1014R    CD11b整合素αM/巨噬细胞表面分子抗体
xy-0468R    CD31血小板内皮细胞黏附分子-1抗体
xy-0195R    CD31血小板内皮细胞黏附分子1抗体
xy-0646R    CD34CD34抗体
xy-1100R    CD36CD36抗体
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xy-7090R    CARD17凋亡加强结构域蛋白17抗体
xy-7085R    CARD4凋亡加强结构域蛋白4抗体
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xy-9080R    CKI gamma 3酪蛋白激酶1γ3/CKI γ3抗体
xy-7089R    CARD9凋亡加强结构域蛋白9抗体
xy-13920R    Cholesterol Oxidase胆固醇氧化酶抗体
xy-6859R    Caspase 14半胱胺酸蛋白酶蛋白14抗体
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xy-10045R    CSFV猪瘟病毒抗体
xy-10045M    CSFV猪瘟病毒抗体
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xy-12111R    CHRNA10烟碱型乙酰胆碱受体α10/AChRα10抗体
xy-12112R    CHRNA6烟碱型乙酰胆碱受体α6/AChRα6抗体
xy-12113R    CHRNA9烟碱型乙酰胆碱受体α9/AChRα9抗体
xy-12114R    CHRND烟碱型乙酰胆碱受体δ/AChRδ抗体
xy-7088R    CARD8凋亡加强结构域蛋白8抗体
xy-6854R    CARD7凋亡加强结构域蛋白7抗体
xy-6857R    beta COPβ衣被蛋白抗体
xy-6858R    Caspase 4+Caspase 11半胱胺酸蛋白酶4/11抗体