锌指蛋白结构域ZFYVE28抗体
英文名称 ZFYVE28
中文名称 锌指蛋白结构域ZFYVE28抗体
别 名 hLst2; Lateral signaling target protein 2 homolog; LST2; LST2_HUMAN; LYST2; MGC43699; MGC61592; zfyve28; Zinc finger FYVE domain containing 28; Zinc finger FYVE domain-containing protein 28.
说 明 书 0.2ml
研究领域 细胞生物 免疫学 信号转导 生长因子和激素
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 96kDa
细胞定位 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZFYVE28
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
ZFYVE28 is an 887 amino acid protein that contains one FYVE-type zinc finger, which mediates the interaction with PI3P (phosphatidylinositol 3-phosphate). ZFYVE28 functions as a negative regulator of EGFR (epidermal growth factor receptor) by promoting its degradation in endosomes when not monoubiquinated on Lys-87. In the absence of monoubiquination, ZFYVE28 localizes to the early endosome membrane, while it localizes to the cytosol when it is monoubiquinated. There are five isoforms of ZFYVE28 that are produced as a result of alternative splicing events.
Function:
Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated.
Subcellular Location:
Cytoplasm > cytosol. Early endosome membrane. Localizes to early endosome membrane in absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated.
Post-translational modifications:
Monoubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes.xy-6932R DEC2转录调节因子DEC2抗体
xy-7598R SPHK2鞘氨醇激酶2抗体
xy-7599R STK3丝氨酸/苏氨酸蛋白激酶3抗体
xy-0437R Streptavidin链酶亲和素抗体
xy-9855R SLN肌脂蛋白抗体
xy-7576R SEN1细胞衰老相关蛋白1抗体
xy-8681R Spermine synthase精胺合成酶抗体
xy-9635R SLC39A11溶质载体家族39成员11抗体
xy-4867R p70 S6 kinase beta核糖体蛋白S6激酶1抗体
xy-8455R SCNN1D上皮钠离子通道蛋白D/δENaC抗体
xy-9871R Sorcin抗药蛋白抗体
xy-8518R SPP24分泌性磷蛋白24抗体
xy-11503R SORCS3液泡蛋白分选受体SORCS3抗体
xy-9491R SOSSC单链DNA结合蛋白相互作用蛋白1
xy-4906R SLC40A1细胞膜铁转运蛋白FP1抗体
xy-9654R pan 14-3-314-3-3蛋白抗体
xy-11400R Synaptotagmin X突触结合蛋白10抗体
xy-7545R Scavenger Receptor BII清道夫受体B2抗体
xy-9715R Sox9a转录因子sox9a抗体
xy-6475R SGK3丝氨酸/苏氨酸蛋白激酶Sgk3抗体
xy-6849R SLPI分泌型白细胞蛋白酶YZ因子抗体
xym-0861M 2,4-D(24D1)2，4-二氯苯氧乙酸(除草剂)单克隆抗体
xy-7639R SLC14A1尿素转运型糖蛋白抗体
xy-7667R SLTM雌激素诱导的转录调制器抗体
xy-0237R 14-3-3 Alpha + Beta + Gamma + Delta + Epsilon14-3-3蛋白/14-3-3 α/β/γ/δ/ε亚型抗体
xy-0861R 2,4-D2，4-二氯苯氧乙酸(除草剂)抗体
xy-1124R 5-HTR1A5-羟色胺受体1A抗体
xy-1126R 5-HT/5 Hydroxy Tryptophan5羟色胺抗体
xy-1125R 5-HTR1B5-羟色胺受体1B抗体
xy-3502R Synapsin II神经突触素2抗体
xy-9156R RNF142环指蛋白142抗体
xy-1906R SYT3突触结合蛋白3抗体
