Human Cellexp Human Recombinant Noggin

Human Cellexp Human Recombinant Noggin
Product Name: Human Cellexp Human Recombinant Noggin
Alternate Name/Synonyms: SYM1, SYNS1, NOG.
Gene Symbol: NOG
Accession #: Q13253
Gene ID: 9241
Source: Human 293 cell expressed
Appearance: Lyophilized
Physical Form Description: Lyophilized in PBS.
Molecular Weight: 65 kDa, homodimer, glycosylated
Purity by SDS-PAGE: > 95%
Purity by HPLC: N/A
Endotoxin Level: < 1.0 EU per 1 μg of protein
Biological Activity: ED₅₀ is typically 20 to 100 ng/mL. The specific activity was determined by the dose-dependent inhibition of rhBMP4 induced alkaline phosphate production by ATDC5 cells.
Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Storage Temp.: -80°C
Shipping: Gel pack
Background Information: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis.
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.