上海雅吉生物科技有限公司生产/代理进口原装/分装抗体 :Anti-phospho-Androgen Receptor (Ser595) 磷酸化雄激素受体抗体
英文名称 Anti-phospho-Androgen Receptor (Ser595)
中文名称 磷酸化雄激素受体抗体
产品类型 一抗 磷酸化抗体
抗体来源 Rabbit
克隆号 Polyclonal
交叉反应 hu, rat, mo
蛋白分子量 Predicted Molecular Weight: 101kDa
性状 Lyophilized or Liquid
浓度 1mg/1ml
免疫原 KLH conjugated Synthesised phosphopeptide derived from human Androgen Receptor around the phosphorylation site of Ser595.
亚型 IgG
产品应用 WB=1:100-500 Elisa=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1/20-1/100
(石蜡切片需做抗原修复)
研究领域 肿瘤
产品介绍 Androgen receptor (AR) belongs to the super-family of nuclear hormone receptors that employ complex molecular mechanisms to guide the development and physiological functions of their target tissues. In mammals, exposure to androgens early in development is essential for masculinization of the male reproductive phenotype. Androgen stimulation results in cell proliferation in both the development of prostate and malignant prostate. Data from animal and human studies indicate that sex steroids have important skeletal effects. Androgens clearly enhance bone size, likely through effects on periosteal bone formation. Similarly to other steroid receptors, AR is a phosphoprotein, but the functional significance of the covalent receptor modification by phosphorylation has remained enigmatic.
类固醇受体(Steroid Receptors)
AR是一个由920个氨基酸组成的蛋白质,位于雄激素靶组织细胞中或细胞表面上的特异分子部位或结构。
AR在前列腺癌中起着重要的作用,研究表明AR的表达与组织分型形成一定的相关性 ,AR在高分化的肿瘤中表达较多,而在低分化的肿瘤中表达较少。用于前列腺癌的检测,指导临床ZL,目前可用于乳腺癌、食道癌等各项肿瘤的研究。
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