Source: | Penicillium sp. |
Synonyms | Citreoviridin A |
Description: | Neurotoxic mycotoxin from Penicillium toxicarium, Penicillium ochrosalmoneum, Penicillium ochrosalmoneum, Aspergillus terreus, Penicillium citreo-viride and several other related fungi. Citreoviridin is believed to be the cause of the Acute Cardiac Beri-Beri disease. |
CAS number: | 25425-12-1 |
Merck index: | 14: Not listed |
Molecular weight: | 412 |
Structure: | Citreoviridin |
Molecular Formula: | C23H30O6 |
Solubility information: | Citreoviridin is soluble in benzene, ethanol, chloroform, ether, dichloromethane. Citreoviridin is hardly soluble in water (enough to give it yellow color) and hexane |
Specifications | |
Appearance: | Orange-yellow powder |
Purity: | At least 97% by TLC, HPLC |
λmax: | 390, 294, 204nm |
Melting point | 110°C |
Solubility | 10 mg of Citreoviridin gives clear yellow solution in 1 ml of DMSO, Methanol, Dichloromethane. |
Storage | -18°C, PROTECT FROM LIGHT |
Applications | As other Aurovertin group members, Citreoviridin binds to and inhibit mitochondrial ATPase, thereby uncoupling oxidative phosphorylation. Aurovertins are used as biochemical tools. |
Warnings | |
Classification | Aurovertin class mycotoxin |
Related products | |
| For Research use only. Not for Human or Drug use GMP/API grade available on request Citreoviridin by Fermentek is not produced from or contains any ingredients from animal origin. No genetically modified organisms are used. |
Publications | |
| Vieta I, Savarino A, Papa G, Vidotto V, Cantamessa C, Pugliese A. In vitro inhibitory activity of citreoviridin against HIV-1 and an HIV-associated opportunist: Candida albicans. J Chemother. 1996 Oct;8(5):351-7 |
| Sayood SF, Suh H, Wilcox CS, Schuster SM. Effect of citreoviridin and isocitreoviridin on beef heart mitochondrial ATPase. Arch Biochem Biophys. 1989 May 1;270(2):714-21. |
| Wicklow DT, Stubblefield RD, Horn BW, Shotwell OL. Citreoviridin levels in Eupenicillium ochrosalmoneum-infested maize kernels at harvest. Appl Environ Microbiol. 1988 May;54(5):1096-8. |
| Nishie K, Cole RJ, Dorner JW. Toxicity of citreoviridin. Res Commun Chem Pathol Pharmacol. 1988 Jan;59(1):31-52. |
| Gause EM, Buck MA, Douglas MG. Binding of citreoviridin to the beta subunit of the yeast F1-ATPase. J Biol Chem. 1981 Jan 25;256(2):557-9. |
| Satre M, Bof M, Vignais PV. Interaction of Escherichia coli adenosine triphosphatase with aurovertin and citreoviridin: inhibition and fluorescence studies. J Bacteriol. 1980 Jun;142(3):768-76. |
| Linnett PE, Mitchell AD, Osselton MD, Mulheirn LJ, Beechey RB. Citreoviridin, a specific inhibitor of the mitochondiral adenosine triphosphatase. |