标准品蛇形霉素标准品（DAS） Diacetoxyscirpenol Sta..._详细资料

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蛇形霉素标准品（DAS） Diacetoxyscirpenol Standard

Source: Fusarium sp

Synonyms Anguidin, Anguidine

Description: Diacetoxyscirpenol is a mycotoxin belonging to 12,13-epoxytrichothecene group, produced by several Fusarium strains together with some other toxins such as T2 and HT2 toxins. Causes fusarium toxicosis in farm animals.

CAS number: 2270-40-8

Merck index: Not listed

Molecular weight: 366.4

Structure:

Molecular Formula: C₁₉H₂₆O₇

Solubility
information: Soluble in moderay polar solvents, such as chloroform, diethyl ether, ethyl acetate, and acetone

Specifications

Appearance: White powder.

Purity: At least 97% by TLC

λ_max:

Melting point 160°C- 164°C

Solubility Clear colorless solution at 10 mg / 1 cc methanol
Clear colorless solution at 10 mg / 1 cc dichloromethane

Storage +4°C.

Applications Diacetoxyscirpenol （Anguidine） and its derivates possess anticancer properties.
Diacetoxyscirpenol （Anguidine） inhibits initiation of protein synthesis, resulting in the death of rapidly proliferating cells. Diacetoxyscirpenol （Anguidine） also has been shown to both potentiate and protect against the cytotoxic effects of other drugs.

There were 14 clinical trials reported, all in the area of colorectal tumors and leukemia. No records found after 1985.

Apoptosis inducement.

Warnings diacetoxyscirpenol is a teratogen

Classification trichothecene mycotoxin
Apoptosis inducer

Related products
T2 toxin , Vomitoxin （deoxynivalenol） , Diacetoxyscirpenol

For Research use only. Not for Human or Drug use
GMP/API grade available on request
diacetoxyscirpenol by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used.

Publications

Lee DH, Park T, Kim HW.
Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with Diacetoxyscirpenol （Anguidine） mycotoxins.
Biol Pharm Bull. 2006 Apr;29（4）:648-54.

Mizuno S.
Mechanism of inhbition of protein systhesis initiation by Diacetoxyscirpenol （Anguidine） and fusarenon X in the reticulocyte lysate system.
Biochim Biophys Acta. 1975 Mar 10;383（2）:207-14.

Goodwin W, Haas CD, Fabian C, Heller-Bettinger I, Hoogstraten B.
Phase I evaluation of anguidine （diacetoxyscirpenol, NSC-141537）.
Cancer. 1978 Jul;42（1）:23-6.

Rosenstein Y, Lafarge-Frayssinet C, Lespinats G, Loisillier F, Lafont P, Frayssinet C.
Immunosuppressive activity of Fusarium toxins. Effects on antibody synthesis and skin grafts of crude extracts, T2-toxin and Diacetoxyscirpenol （Anguidine） .
Immunology. 1979 Jan;36（1）:111-7.

Craddock VM.
Effect of the trichothecene mycotoxin diacetoxyscirpenol on nitrosamine-induced oesophageal cancer and on relevant enzymes in oesophagus and liver.
IARC Sci Publ. 1987;（84）:266-9.

Diggs CH, Scoltock MJ, Wiernik PH.
Phase II evaluation of Diacetoxyscirpenol （Anguidine）（NSC-141537） for adenocarcinoma of the colon or rectum.
Cancer Clin Trials. 1978 Winter;1（4）:297-9.

Claridge CA, Schmitz H, Bradner WT. Antitumor activity of some microbial and chemical transformation products of anguidine （4,15- diacetoxyscirpeneol）.
Cancer Chemother Pharmacol 1979;2（3）:181-2.

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Source:	Fusarium sp
Synonyms	Anguidin, Anguidine
Description:	Diacetoxyscirpenol is a mycotoxin belonging to 12,13-epoxytrichothecene group, produced by several Fusarium strains together with some other toxins such as T2 and HT2 toxins. Causes fusarium toxicosis in farm animals.
CAS number:	2270-40-8
Merck index:	Not listed
Molecular weight:	366.4
Structure:
Molecular Formula:	C₁₉H₂₆O₇
Solubility information:	Soluble in moderay polar solvents, such as chloroform, diethyl ether, ethyl acetate, and acetone
Specifications
Appearance:	White powder.
Purity:	At least 97% by TLC
λ_max:
Melting point	160°C- 164°C
Solubility	Clear colorless solution at 10 mg / 1 cc methanol Clear colorless solution at 10 mg / 1 cc dichloromethane
Storage	+4°C.
Applications	Diacetoxyscirpenol （Anguidine） and its derivates possess anticancer properties. Diacetoxyscirpenol （Anguidine） inhibits initiation of protein synthesis, resulting in the death of rapidly proliferating cells. Diacetoxyscirpenol （Anguidine） also has been shown to both potentiate and protect against the cytotoxic effects of other drugs. There were 14 clinical trials reported, all in the area of colorectal tumors and leukemia. No records found after 1985. Apoptosis inducement.
Warnings	diacetoxyscirpenol is a teratogen
Classification	trichothecene mycotoxin Apoptosis inducer
Related products	T2 toxin , Vomitoxin （deoxynivalenol） , Diacetoxyscirpenol
	For Research use only. Not for Human or Drug use GMP/API grade available on request diacetoxyscirpenol by Fermentek is not produced from or contains any ingredients from animal origin. No genetically modified organisms are used.
Publications
	Lee DH, Park T, Kim HW. Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with Diacetoxyscirpenol （Anguidine） mycotoxins. Biol Pharm Bull. 2006 Apr;29（4）:648-54.
	Mizuno S. Mechanism of inhbition of protein systhesis initiation by Diacetoxyscirpenol （Anguidine） and fusarenon X in the reticulocyte lysate system. Biochim Biophys Acta. 1975 Mar 10;383（2）:207-14.
	Goodwin W, Haas CD, Fabian C, Heller-Bettinger I, Hoogstraten B. Phase I evaluation of anguidine （diacetoxyscirpenol, NSC-141537）. Cancer. 1978 Jul;42（1）:23-6.
	Rosenstein Y, Lafarge-Frayssinet C, Lespinats G, Loisillier F, Lafont P, Frayssinet C. Immunosuppressive activity of Fusarium toxins. Effects on antibody synthesis and skin grafts of crude extracts, T2-toxin and Diacetoxyscirpenol （Anguidine） . Immunology. 1979 Jan;36（1）:111-7.
	Craddock VM. Effect of the trichothecene mycotoxin diacetoxyscirpenol on nitrosamine-induced oesophageal cancer and on relevant enzymes in oesophagus and liver. IARC Sci Publ. 1987;（84）:266-9.
	Diggs CH, Scoltock MJ, Wiernik PH. Phase II evaluation of Diacetoxyscirpenol （Anguidine）（NSC-141537） for adenocarcinoma of the colon or rectum. Cancer Clin Trials. 1978 Winter;1（4）:297-9.
	Claridge CA, Schmitz H, Bradner WT. Antitumor activity of some microbial and chemical transformation products of anguidine （4,15- diacetoxyscirpeneol）. Cancer Chemother Pharmacol 1979;2（3）:181-2.

标准品 蛇形霉素标准品（DAS） Diacetoxyscirpenol Sta...

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标准品蛇形霉素标准品（DAS） Diacetoxyscirpenol Sta...