Source: | Penicillium simplicissimum |
Synonyms | |
Description: | Verruculogen is a tremorgenic mycotoxin. |
CAS number: | 12771-72-1 |
Merck index: | |
Molecular weight: | 511.6 |
Structure: | |
Molecular Formula: | C27H33N3O7 |
Solubility information: | DMSO, Methanol, Ethanol |
Specifications | |
Appearance: | White powder |
Purity: | At least 98% by TLC, HPLC |
λmax: | |
Melting point | 230°C -233°C |
Solubility | |
Storage | -20°C. |
Applications | Verruculogen decreases GABA levels in CNS. Tremorgenic doses of verruculogen increase the number and decrease the affinity of DHP receptors in rat cortex. Verruculogen is a potent inhibitor of high conductance Ca activated K (maxi-K) channel. |
Classification | tremorgen mycotoxin |
Warnings | |
Related products | |
| For Research use only. Not for Human or Drug use GMP/API grade available on request No genetically modified organisms are used. |
Publications | |
| Kosalec I, Klaric MS, Pepeljnjak S. Verruculogen production in airborne and clinical isolates of Aspergillus fumigatus Fres. Acta Pharm. 2005 Dec;55(4):357-64 |
| Sabater-Vilar M, Nijmeijer S, Fink-Gremmels J. Genotoxicity assessment of five tremorgenic mycotoxins (fumitremorgen B, paxilline, penitrem A, verruculogen, and verrucosidin) produced by molds isolated from fermented meats. J Food Prot. 2003 Nov;66(11):2123-9 |
| BMC Microbiol. 2007 Jan 23;7:5. Verruculogen associated with Aspergillus fumigatus hyphae and conidia modifies the electrophysiological properties of human nasal epithelial cells. Khoufache K, Puel O, Loiseau N, Delaforge M, Rivollet D, Coste A, Cordonnier C, Escudier E, Botterel F, Bretagne S. |