Source: | Penicillium expansum | Synonyms | Clavacin, Claviformin, Mycoin C3 | Description: | Patulin: a cytostatic, antibacterial mycotoxin. Inhibits potassium uptake, activates the p38 kinase. | CAS number: | 149-29-1 | Merck index: | 12, 7185 | Molecular weight: | 154.1 | Structure: | | Molecular Formula: | C7H6O4 | Solubility information: | Patulin is soluble in DMSO, Methanol, Ethanol, water | Specifications | | Appearance: | White crystalline solid. | Purity: | At least 98% by TLC, HPLC | λmax: | 276 | Melting point | 105°C-111°C | Solubility | Clear colorless solution at 10mg of Patulin in 1 ml of DMSO | Storage | -20°C. Protect from light. | Applications | | Warnings | TOXIC. Patulin may be lethal if swallowed, inhaled or adsorbed through skin. Patulin has been proven to be carcinogenic and potentially mutagenic. | Classification | Lactone Mycotoxin Cell signaling reagent; apopotosis inducer | Related products | | | For Research use only. Not for Human or Drug use GMP/API grade available on request Patulin by Fermentek is not produced from or contains any ingredients from animal origin. No genetically modified organisms are used. | Publications | | | Fuchs S, Sontag G, Stidl R, Ehrlich V, Kundi M, Knasmüller S. Detoxification of patulin and ochratoxin A, two abundant mycotoxins, by lactic acid bacteria. Food Chem Toxicol. 2008 Apr;46(4):1398-407 | | McLaughlin J, Lambert D, Padfield PJ, Burt JP, O'Neill CA. Toxicol In Vitro. 2009 Feb;23(1):83-9. The mycotoxin patulin, modulates tight junctions in caco-2 cells. | | Saxena N, Ansari KM, Kumar R, Dhawan A, Dwivedi PD, Das M. Patulin causes DNA damage leading to cell cycle arrest and apoptosis through modulation of Bax, p(53) and p(21/WAF1) proteins in skin of mice. Toxicol Appl Pharmacol. 2009 Jan 15;234(2):192-201 | | Wu TS, Liao YC, Yu FY, Chang CH, Liu BH. Mechanism of patulin -induced apoptosis in human leukemia cells (HL-60). Toxicol Lett. 2008 Dec 15;183(1-3):105-11 | | Luft P, Oostingh GJ, Gruijthuijsen Y, Horejs-Hoeck J, Lehmann I, Duschl A. Patulin influences the expression of Th1/Th2 cytokines by activated peripheral blood mononuclear cells and T cells through depletion of intracellular glutathione. Environ Toxicol. 2008 Feb;23(1):84-95. | |