货号:IGG1001- 盐酸西替利嗪,Cetirizine Dihydrochloride

Description
盐酸西替利嗪,Cetirizine Dihydrochloride是一种抗组织胺剂，能够YZ组胺H1受体，IC50为0.65 μM。

• Synonyms: UCB P071, Reactine, Zyrtec, Alerlisin, Alercet
• Target 1: histamine H1-receptors
• Product category: 小分子YZ剂
• Purity: >98%
• Solubility: Soluble in DMSO or water (up to 100 mM)
• Storage: Store solid at -20 oC for the stability of three years.
• Stock: Yes

 IGG1001-Cetirizine Dihydrochloride

Cetirizine Dihydrochloride，>98%

【英文同义名】：UCB P071, Reactine, Zyrtec, Alerlisin, Alercet

【中文同义名】：盐酸西替利嗪

产品描述

盐酸西替利嗪,Cetirizine Dihydrochloride是一种抗组织胺剂，能够YZ组胺H1受体，IC₅₀为0.65 µM。Cetirizine Dihydrochloride对H1受体的选择性是钙离子通道α1, D2, 5-HT2和M1受体的15倍以上 ^[1]。Cetirizine Dihydrochloride通过减少组胺，缓激肽，和过敏原诱导的水疱和耀斑反应;降低单核细胞和T淋巴细胞趋化作用; 减少嗜酸性粒细胞反应;减少上皮细胞间粘附分子表达而有效ZL皮肤炎 ^[1,2]。Cetirizine Dihydrochloride的作用也具有非H1依赖性，如YZ嗜碱细胞及肥大细胞来源的炎症预成形介体组胺，类胰蛋白酶和Leu-kotrienes;YZ嗜酸性粒细胞趋化; 减少嗜酸性粒细胞生存等 ^[3]。

靶点

化学特性

储存液配制

结构式

使用浓度(仅作参考)

的具体使用浓度请参考相关文献，并根据自身实验条件（如实验目的，细胞种类，培养特性等）进行摸索和优化。

参考文献

[1] Campoli-Richards DM, et al. A review of its pharmacological properties and clinical potential in allergic rhinitis, pollen-induced asthma, and chronic urticaria. Drugs. 40(5):762-81 (1990).

[2] Curran MP, et al. Cetirizine: a review of its use in allergic disorders. Drugs. 64:523–561 (2004).

[3] Griffin JS, et al. An open clinical trial on the efficacy of cetirizine hydrochloride in the management of allergic pruritus in cats. The Canadian Veterinary Journal. 53(1):47-50(2012).