Imatinib inhibits c-kit, PDGFR and c-ABL by perfectly binding to adenosine triphosphate (ATP)-binding sites of the c-kit protooncogene product, plaet-derived growth factor receptor (PDGFR), and abelson kinase (c-ABL). http://www.creative-enzymes。。com/product/Imatinib-Gleevec-_2034.html