The Bio-Assembler™ System 三维细胞培养系统
The Bio-Assembler™ system cultures cells in three-dimensions by magnetic levitation. The Bio-Assembler™uses nanoparticle-based Nanoshuttle-PL solution to deliver magnetic nanoparticles to cells. Magnetic drives then levitate cells to create the 3D cell growth environment. Using the Bio-Assembler™ is as easy as performing standard monolayer (2D) culture. Preparation time and cell manipulation requirements are equivalent to 2D culture.
Advantages of n3D’s 3-Dimensional Cell Culturing System:
Rapid formation of 3D structures and cell-cell interactions
More accurate representation of in vivo tissue
Compatibility with virtually any cell type including primary and stem cells
Compatibility with any media type, standard culturing protocols, and diagnostic techniques
3D co-culturing capabilities
Unique capability for moving and shaping tissue, applicable to invasion studies and tissue engineeringAs Simple as 2D
There are only two simple additional steps that differentiate the Bio-Assembler™ from 2D cell culturing:1) Adding the Nanoshuttle to cells prior to levitation
2) Placing the magnetic drive on top of the cell culturing plate
3D细胞培养,让细胞有家的感觉
作者:小茜来源:生物通2010-3-19 10:09:03
2009年末,3D电影阿凡达风靡,细胞的世界其实也有3D的精彩,一个来自Houston医学研究ZX的研究团队开发出一种3D细胞培养技术,相关成果文章公布在新一期的Nature Nanotechnology上。
相比阿凡达的3D技术,在实验室用3D技术培养细胞简单得多,只要在培养皿中提供一个磁力,使得细胞悬浮在培养皿中就可以轻松获得,这样细胞在培养皿中的环境更像在组织中生长的环境。
传统细胞培养技术在模拟细胞体内生存环境方面做得还不够。3D细胞培养技术的发明就是为了在细胞培养过程中,为细胞提供一个更加接近体内生存条件的微环境。
文章的作者之一Tom Killian副教授表示,用3D细胞培养技术可使得细胞状态保持与在人体内生长的相似,这对药物筛选等研究具有重要的意义。如果说,我们可以提高药物筛选的可信度,只要提高10%,就能节省1亿美金的研发经费。
德克萨斯大学Anderson癌症ZX的David H.Koch表示,在癌症研究中,3D技术显得更为关键,我们下一步的计划是将这些3D技术用于癌症方面的研究。
3D细胞培养技术为细胞提供一个更加接近体内生存条件的微环境,感觉就像“在家里一样”。该技术不仅仅应用于基于细胞的高通量药物筛选,还可以应用于医学中。
3D细胞培养,细胞生长更接近体内环境——感觉像“在家里一样”。因此,研究者通过3D培养技术从高通量筛选、毒物筛选及其它筛选中来获得接近体内真实情况的数据