D4000 Sigma 反式-脱氢雄甾酮 trans-Dehydroandrosterone

反式-脱氢雄甾酮 trans-Dehydroandrosterone
≥99% 
 
别名: 3β-羟基-5-雄烯-17-酮 DHEA 去氢表雄酮 普拉睾酮 脱氢异雄酮 雄素-5-烯-3β-醇-17-酮

CAS号 53-43-0
经验分子式（希尔表示法） C19H28O2
分子量 288.42

反式-脱氢雄甾酮 trans-Dehydroandrosterone
性质
Related Categories Androgen, Bioactive Small Molecules, Biochemicals Found in Plants - sorted by compound type, Cancer Research, Cell Biology,
Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, D-DIF, Hormones, Nutrition Research, Steroid, Steroid Hormones, Tumor Growth Regulation, Tumor Promotors

assay    ≥99% 
drug control    Home Office Schedule 4.2regulated under CDSA - not available from Sigma-Aldrich Canada 
mp    149-151 °C（lit.） 
Gene Information    Research your gene in Your Favorite Gene powered by Ingenuity
human ... GABRA1（2554）, GABRA2（2555）, GABRA3（2556）, GABRA4（2557）, GABRA5（2558）, GABRA6（2559）, GABRB1（2560）, GABRB2（2561）, GABRB3（2562）, SERPINA6（866）
rat ... Ar（24208） 

Biochem/physiol Actions
Dehydroandrosterone （DHEA） is a negative modulator of GABAA receptors. It is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. DHEAs conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors.

Negative modulator of GABAA receptors. Steroid secreted by the adrenal gland with both estrogenic and androgenic properties. Its conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors. At high but physiologically valid concentrations, DHEA inhibits proliferation of chromaffin progenitor cells and induces dopaminergic differentiation.