Cell Contraction Assay （Collagen-Ba..._详细资料

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Cell Contraction Assay （Collagen-Based）
Wound healing is comprised of 3 processes: epithelialization, connective tissue deposition, and contraction.
The contraction process is believed to be mediated by specialized fibroblasts known as myofibroblasts. 3D col-
lagen gels have been widely used in fibroblast contraction studies.

Our Cell Contraction Assay provides a simple system to assess cell contractivity and to screen for cell contrac-
tion mediators. The system uses a 3D collagen matrix to measure changes in the collagen gel size. An optional
contraction inhibitor is provided.

6
Control

5

4

3

2

1

0

BDM

0

50

100

150

Assay Principle for the Collagen-Based Cell Contraction
Assay.

Time （min）

Contraction Inhibition by BDM.5 x 10⁵ COS-7 cells in 0.5 mL
collagen gel lattice were cultured for 2 days. Before initiation of
contraction, cells were pretreated with 10mM BDM for 1 hour.
The change in gel diameter （mm） was measured with a ruler at
various times following release.

Product Name
Cell Contraction Assay

Detection
Light Microscopy

Size
24 Assays

Catalog Number
CBA-201

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