Teicoplanin/替考拉宁
产品编号:T002
产品规格:100mg/1g
CAS Number | 61036-62-2 |
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Molecular Formula |
C88H97Cl2N9O33 |
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Molecular Weight | 1879.7 |
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Form | Powder |
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Solubility | Sparingly |
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Storage Conditions | 2 - 8 °C |
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References
Murphy, S., and R. J. Pinney. "Teicoplanin or Vancomycin in the Treatment of Gram–positive Infections?" Journal of Clinical Pharmacy and Therapeutics 20.1 (2008): 5-11. Web. 15 Nov. 2012.
Description
Teicoplanin is a glycopeptide antibiotic composed of a mixture of related compounds used to treat infections caused by methicillin resistant Gram positive bacteria. Teicoplanin is sparingly soluble in water.
Mechanism
Teicoplanin prevents peptidoglycan synthesis and polymerization by two separate mechanisms. One mechanism prevents N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) from linking together forming the peptidoglycan backbone. The second mechanism prevents cross-linking between amino acid residues in the peptidoglycan chain. This mechanism is nearly identical to vancomycin; however, teicoplanin is considered a safer drug due to its lower nephrotoxicity and ototoxicity.
Spectrum
Teicoplanin targets primarily gram positive bacteria especially those resistant to methicillin. These include MRSA and Enterococcus faecalis.Microbiology Applications