P010 Piperacillin sodium/哌拉西林钠

Piperacillin sodium/哌拉西林钠
产品编号：P010 
产品规格：5g/10g

CAS Number	59703-84-3
Molecular Formula	C23H26N5NaO7S
Molecular Weight	539.54 g/mol
Form	Powder
Appearance	White or off-white powder
Purity Level	≥95.0%
Solubility	Methanol: Freely soluble Water: Freely soluble
Source	Pseudomonas sp.
Water Content (Karl Fisher)	No more than 1.0%
pH	Between 5.5 and 7.5, in a 400 mg/mL solution
Melting Point	183-185 °C
Storage Conditions	2-8 °C

Description
Piperacillin is an extended spectrum β-lactam antibiotic and is resistant to many β-lactamases.
TOKU-E offers two forms of piperacillin: piperacillin (P017) and piperacillin sodium (P010). Piperacillin is sparingly soluble in aqueous solution at 0.119 mg/mL. Piperacillin sodium is freely soluble in aqueous solution.
Mechanism
β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.
Spectrum
Piperacillin is a broad spectrum antibiotic targeting a wide range of susceptible gram positive and gram negative bacteria.
Microbiology Applications