M002 Meropenem, USP/美罗培南, USP

Meropenem, USP/美罗培南, USP
产品编号：M002 
产品规格：50mg

CAS Number	96036-03-2
Molecular Formula	C17H25N3O5S
Molecular Weight	383.46 g/mol
Form	Powder
Appearance	Almost white or yellowish crystalline powder
Purity Level	98.0-101.1 %
Solubility	Water: 5.63 mg/mL
Source	Synthetic
Water Content (Karl Fisher)	Between 11.4% and 13.4%
pH	4.0-6.0
Boiling Point	627.4 °C
Flash Point	333.2 °C
Optical Rotation	-17.0° to -21.0° (Test solution: 5 mg/mL, in water.)
Storage Conditions	2-8 °C

Description
Meropenem is a β-lactam antibiotic in the carbapenem class and is sparingly soluble in aqueous solution (5.63 mg/mL).
Mechanism
β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. like many carbapenems, meropenem is highly resistant to the degradative effects of β-lactamases.
Spectrum
Meropenem is a broad spectrum antibiotic targeting a wide range of bacteria especially those which cause meningitis.
Microbiology Applications