Econazole nitrate/硝酸益康唑
产品编号:E001
产品规格:5g/25g/100g
CAS Number | 68797-31-9 |
---|
Molecular Formula | C18H15Cl3N2O · HNO3 |
---|
Molecular Weight | 444.70 g/mol |
---|
Form | Powder |
---|
Appearance | White or almost white crystalline powder |
---|
Purity Level | ≥95.0% |
---|
Solubility | Water: Very slightly soluble
Note: Soluble in a 1:1 mixture of chloroform and methanol with heat and sonication. |
---|
Source | Synthetic |
---|
Water Content (Karl Fisher) | Loss on drying: <0.5% |
---|
Boiling Point | 533.8 °C |
---|
Melting Point | 162 -166 °C |
---|
Flash Point | 276.6 °C |
---|
Storage Conditions | 2-8 °C |
---|
Description
Econazole nitrate is an insoluble (0.00148 mg/mL) imidazole antifungal that specifically targets the cell membrane of fungi.
Mechanism
Econazole nitrate increases cell permeability by inhibiting enzymes involved in ergosterol synthesis. The increase of permeability has a toxic effect on the fungi and leads to cell death.
Spectrum
Econazole nitrate targets fungi responsible for tinea (ringworm) especially Trichophyton and Microsporum species.
Microbiology Applications