C083 Colistin sulfate/硫酸粘菌素

Colistin sulfate/硫酸粘菌素
产品编号：C083 
产品规格：100mg/1g

CAS Number	1264-72-8
Molecular Formula	C52H98N16O13 ·2.5 H2SO4
Molecular Weight	2801.27 g/mol
Form	Powder
Appearance	White or almost white, hygroscopic powder
Purity Level	>19,000 u/mg
Solubility	Acetone: Practically insoluble Ethanol (96%) Slightly soluble Water: Freely soluble
Source	Bacillus Polymyxa subsp.
Water Content (Karl Fisher)	Loss on drying: <7.0%
pH	4.0 to 6.0
Boiling Point	1537.3 °C
Melting Point	200-220 °C
Flash Point	883.5 °C
Optical Rotation	-63o to -73o (dried substance)
Storage Conditions	2-8 °C.

Description
Colistin is a unique sparingly soluble cyclic polypeptide antibiotic known as a polymyxin.
TOKU-E offers two forms of colistin: colistin sulfate (C039) and colistin sodium methanesulfonate (C073). Both forms of colistin are freely soluble in aqueous solution.  Colistin sodium methanesulfonate (CMS) is considered an inactive prodrug which means it is inactive until converted into colistin by cellular enzymes.  Colistin sulfate (colistin) however, is the end product of CMS and does not require molecular conversion for antimicrobial properties.
Mechanism
Colistin has a bactericidal effect on bacteria by targeting the cell membrane and modifying its permeability.
Spectrum
Colistin primarily targets and disrupts the cell wall of gram negative bacteria.
Microbiology Applications