C021 Ceftizoxime sodium/头孢唑肟钠

Ceftizoxime sodium/头孢唑肟钠
产品编号：C021 
产品规格：1g/5g

CAS Number	68401-82-1
Molecular Formula	C13H12N5NaO5S2
Molecular Weight	405.38 g/mol
Form	Powder
Appearance	White or pale yellow crystalline powder
Purity Level	≥95.0%
Solubility	Water: Very soluble
Source	Synthetic
Water Content (Karl Fisher)	<8.5%
pH	6.0-8.0
Melting Point	227 °C
Optical Rotation	+125o to +145o
Storage Conditions	2-8 °C

Description
Ceftizoxime sodium is a third generation cephalosporin antibiotic and is considered very soluble in aqueous solution.
Mechanism
like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases; however, ceftizoxime is stable in the presence of these inactivating enzymes.
Spectrum
Ceftizoxime is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria.
Microbiology Applications