Biological Description
Potent, selective, orally active and brain penetrant mGlu7 receptor agonist. Potently inhibits cAMP accumulation and stimulates GTP binding (EC50 = 64-290 nM) in mGluR7 transfected cells. selective over mGlu1, 2, 3, 4,5, 6, and8, ionotropic receptors (up to 10 μM). Elevates plasma stress hormones in vivo. Induces mGlu7 receptor internalisation in dissociate |