Asc-008 MPEP hydrochloride

Biological Description

Subtype selective and potent non-competitive mGlu₅ antagonist (IC₅₀ = 36 nM). Central effects following systemic administration in vivo.

Useful References

Salt et al (1999) Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Br.J.Pharmacol. 127:1057.



Gasparini et al (1999) 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology 38:1493.



Malherbe et al (2003) Mutational analysis and molecular modelling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine. Mol.Pharmacol. 64:823

 

Our products in action...

Shin et al. (2009) Depolarization-induced slow current in cerebellar purkinje cells does not require metabotropic glutamate receptor 1. J Neurosci abstract



Dickenson et al. (2009) A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPAs, GRIP and liprin-alpha. Molecular Brain 2: 18. abstract

Chemical Information

2-Methyl-6-(phenylethynyl)pyridine hydrochloride

• Desiccate at +4°C


• MW 229.71


• Soluble to 5 mM in water and to 100 mM in ethanol and to 100 mM in DMSO


• C₁₄H₁₁N.HCl


• 96206-92-7