Amoxicillin/Clavulanate (augmentin)/阿莫西林克拉维酸钾
产品编号:A054
产品规格:1g/10g/100g
CAS Number | N/A |
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Molecular Weight | N/A |
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Appearance | off-white or light yellow powder |
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Solubility |
Water ≤11.0%; Single impurity≤2.0%; total impurities≤6.0% |
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Description
Amoxicillin is an extended spectrum β-lactam antibiotic and is similar in structure to ampicillin. Resistance to Amoxicillin is due to β-lactamase enzymes secreted by a resistant cell.
TOKU-E offers three forms of amoxicillin: amoxicillin (A004), amoxicillin sodium salt (A059), and amoxicillin/clavulanate potassium (A054). In aqueous solution, amoxicillin sodium is freely soluble (50 mg/mL) while amoxicillin is sparingly soluble (3.4 mg/mL). Both forms have similar potencies and are suitable for microbiology use; however, amoxicillin sodium is easier to work with in aqueous solution. Clavulanate potassium (clavulanic acid) is a β-lactamase inhibitor which can irreversibly inactivate β-lactamase enzymes of β-lactam resistant microbes preventing them from breaking down β-lactam antibiotics. Amoxicillin can be combined with clavulanate potassium for greater efficacy against β-lactam resistant strains.
Mechanism
like all β-lactams, amoxicillin targets PBP’s (penicillin binding proteins) involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised ultimately leading to the death of the cell.
Spectrum
Amoxicillin targets a wide range of β-lactamase negative gram positive and gram negative bacteria including E. coli and a number of Streptococcus and Staphylococcus species. Because peptidoglycan is synthesized in gram positive and gram negative bacteria, amoxicillin can be used against a wide variety of microbes.
Microbiology Applications